成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の実施者による研究支援と研究高度化の成果として輩出されたデータベース、 ツール、論文および特許を紹介します。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

Jianan Li, Keisuke Yanagisawa, Yasushi Yoshikawa, Masahito Ohue, Yutaka Akiyama (2021)  Plasma protein binding prediction focusing on residue-level features and circularity of cyclic peptides by deep learning Bioinformatics.
Masahito Ohue, Hiroki Watanabe, Yutaka Akiyama (2021)  MEGADOCK-Web-Mito: human mitochondrial protein-protein interaction prediction database. In Proceedings of The 27th International Conference on Parallel & Distributed Processing Techniques and Applications (PDPTA’21). DOI:https://arxiv.org/abs/2105.00445
加藤龍一 (2021)  高エネ機構における結晶化条件探索の自動化 日本結晶学会誌. 63 212-215 DOI:10.5940/jcrsj.63.212
Mitsuhiro Takeda, Yohei Miyanoiri, Tsutomu Terauchi, Masatsune Kainosho (2021)  Conformational features and ionization states of Lys side chains in a protein studied using the stereo-array isotope labeling (SAIL) method Magnetic Resonance. 2 :1,  223-237 DOI:10.5194/mr-2-223-2021
Yamato Sajiki , Satoru Konnai , Zimeng Cai , Kensuke Takada , Tomohiro Okagawa , Naoya Maekawa , Sotaro Fujisawa , Yukinari Kato, Yasuhiko Suzuki , Shiro Murata , Kazuhiko Ohashi (2021)  Enhanced Immunotherapeutic Efficacy of Anti-PD-L1 Antibody in Combination with an EP4 Antagonist. Immunohorizons. 4 :12,  837-850 DOI:10.4049/immunohorizons.2000089 PMID:33443026 
Kazunori D YAMADA, Fangzhou LIN, Tsukasa NAKAMURA (2021)  Developing a novel recurrent neural network architecture with fewer parameters and good learning performance Interdisciplinary Information Sciences. 27 :1,  25-40 DOI:10.4036/iis.2020.R.01
Kazuyuki Saito, Wang Zhou, Shohei Sato, Keita Takubo, Kazunori Furutsu, Ahmed A.B. Mohamed, Euis Maras Purwati, Takashi Ikawa, Shuji Akai (2021)  Regio-Complementary Preparation of 6- and 7-Fluoro-1,2,3,4-tetrahydroquinolines via the Cyclization of Catecholamines Followed by Deoxyfluorination Heterocycles. 103 :2,  DOI:10.3987/COM-20-S(K)56
Naoyuki Kotoku, Hirokazu Matsumoto, Tomoya Hisa, Kazunari Toda, Ryosuke Ishida, Andi Setiawan, Masayoshi Arai (2021)  Fasciospyrinadinone and Fasciospyrinadinol, Novel 3-Alkylpyridine Sesquiterpenoids from An Indonesian Marine Sponge, as Selective Growth Inhibitors of the Cancer Cells Under Nutrient Starvation Heterocycles. 103 :2,  827- DOI:10.3987/COM-20-S(K)50
Kenichi Murai, Shuji Miyazaki, and Hiromichi Fujioka Sourav Basu, Saumen Hajra (2021)  Conjugate Addition Reaction of Indole to Protected 2-Amino-1-Nitroethenes Mediated by Silica Gel Heterocycles. 103 :1,  459-464 DOI:10.3987/COM-20-S(K)5
Kenta Morita, Kenichi Murai, Mitsuhiro Arisawa, Hiromichi Fujioka (2021)  Selective Reduction and Dihydroxylation of α,β-Unsaturated Esters in The Presence of Enals Heterocycles. 103 :1,  311-321 DOI:10.3987/COM-20-S(K)15
Teizo Asano , Tomokazu Ohishi , Junko Takei , Takuro Nakamura , Ren Nanamiya , Hideki Hosono , Tomohiro Tanaka, Masato Sano , Hiroyuki Harada , Manabu Kawada , Mika K Kaneko , Yukinari Kato  (2021)  Anti-HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma Oncology Reports. 46 :2,  173- DOI:10.3892/or.2021.8124 PMID:34184091 
Tomohiro Tanaka, Tomokazu Ohishi, Teizo Asano, Junko Takei, Ren Nanamiya, Hideki Hosono, Masato Sano, Hiroyuki Harada, Manabu Kawada, Mika K Kaneko, Yukinari Kato (2021)  An anti-TROP2 monoclonal antibody TrMab-6 exerts antitumor activity in breast cancer mouse xenograft models ONCOLOGY REPORTS. 46 :1,  132- DOI:10.3892/or.2021.8083 PMID:34013368 
Masatoshi Kanayama , Rintaro Oyama , Masataka Mori , Akihiro Taira , Shinji Shinohara , Taiji Kuwata , Masaru Takenaka , Kazue Yoneda , Koji Kuroda , Takashi Ohnaga , Yukinari Kato , Fumihiro Tanaka (2021)  Novel circulating tumor cell-detection chip combining conventional podoplanin and EGFR antibodies for all histological malignant pleural mesothelioma. Oncol Lett.. 22 :1,  522- DOI:10.3892/ol.2021.12783 PMID:34025789 
Manabu Igarashi , Takatsugu Hirokawa , Yoshihiro Takadate , Ayato Takada (2021)  Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study Viruses. 13 :5,  913- DOI:10.3390/v13050913 PMID:34069246 
Si-Si Liu, Fei Jin, Yi-Shi Liu, Yoshiko Murakami, Yukihiko Sugita, Takayuki Kato, Xiao-Dong Gao, Taroh Kinoshita, Motoyuki Hattori, Morihisa Fujita (2021)  Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit molecules. 26 :18,  5462- DOI:10.3390/molecules26185462 PMID:34576938 
Akinori Morita , Shintaro Ochi , Hidetoshi Satoh , Shohei Ujita , Yosuke Matsushita , Kasumi Tada ,Mihiro Toyoda , Yuichi Nishiyama , Kosuke Mizuno , Yuichi Deguchi , Keiji Suzuki , Yoshimasa Tanaka ,Hiroshi Ueda , Toshiya Inaba , Yoshio Hosoi and Shin Aoki (2021)  A Novel RNA Synthesis Inhibitor, STK160830, Has NegligibleDNA-Intercalating Activity for Triggering A p53 Response, andCan Inhibit p53-Dependent Apoptosis Life. 11 :10,  1087- DOI:10.3390/life11101087 PMID:34685458 
Takatsugu Kosugi, Masahito Ohue (2021)  Quantitative estimate index for early-stage screening of compounds targeting protein-protein interactions. International Journal of Molecular Sciences. 22 :20,  10925- DOI:10.3390/ijms222010925 PMID:34681589 
Effi Haque , Magdalena Smiech , Kamila Luczynska , Marie France Bouchard , Robert Viger , Hidetoshi Kono , Mariusz Pierzchala , Hiroaki Taniguchi (2021)  NRF2 DLG domain mutations identified in Japanese liver can-cer patients affect the transcriptional activity in HCC cell lines International Journal of Molecular Sciences. 22 :10,  5296- DOI:10.3390/ijms22105296 PMID:34069882 
Yuya Monoe, Kentaro Jingushi, Akitaka Kawase, Takayuki Hirono, Ryo Hirose, Yoshino Nakatsuji, Kaori Kitae, Yuko Ueda, Hiroaki Hase, Yuichi Abe, Jun Adachi, Takeshi Tomonaga, Kazutake Tsujikawa (2021)  Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1 International Journal of Molecular Sciences. 22 :9,  4751- DOI:10.3390/ijms22094751 PMID:33947152 
Shuhei Ueda, Masahito Hosokawa, Koji Arikawa, Kiyofumi Takahashi, Mao Fujiwara, Manami Kakita, Taro Fukada, Hiroaki Koyama, Shin-Ichiro Horigane, Keiichi Itoi, Masaki Kakeyama, Hiroko Matsunaga, Haruko Takeyama, Haruhiko Bito, Sayaka Takemoto-Kimura (2021)  Distinctive Regulation of Emotional Behaviors and Fear-Related Gene Expression Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles Frontiers in Molecular Neuroscience. 14 741895- DOI:10.3389/fnmol.2021.741895 PMID:34539345 
Tohru Minamino , Yusuke V Morimoto , Miki Kinoshita , Keiichi Namba (2021)  Multiple roles of flagellar export chaperones for efficient and robust flagellar filament formation in Salmonella. Frontiers in Microbiology. 12 756044- DOI:10.3389/fmicb.2021.756044 PMID:34691007 
Stefanie Kickinger , Maria E K Lie , Akihiro Suemasa , Anas Al-Khawaja1, Koichi Fujiwara , Mizuki Watanabe , Kristine S Wilhelmsen , Christina B Falk-Petersen, Bente Frolund , Satoshi Shuto , Gerhard F Ecker , Petrine Wellendorph (2021)  Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1 Frontiers in Chemistry. 9 736457- DOI:10.3389/fchem.2021.736457 PMID:34595152 
Daiki Yamane, Satsuki Onitsuka, Suyong Re, Hikaru Isogai, Rui Hamada, Tadanari Hiramoto , Eiji Kawanishi, Kenji Mizuguchi, Naoya Shindo, Akio Ojida (2021)  Selective Covalent Targeting of SARS-CoV-2 Main Protease by Enantiopure Chlorofluoroacetamide Biological and medicinal chemistry. DOI:10.33774/chemrxiv-2021-xn1wc
Kaori Fukuzawa, Koichiro Kato, Chiduru Watanabe, Yusuke Kawashima, Yuma Handa, Ami Yamamoto, Kazuki Watanabe, Tatsuya, Kikuko Kamisaka, Daisuke Takaya,Teruki Honma (2021)  Special feature of COVID-19 in FMODB: Fragment molecular orbital calculations and interaction energy analysis of SARS-CoV-2 related proteins ChemRxiv. 61 :9,  4594-4612 DOI:10.33774/chemrxiv-2021-njqc8 PMID:34506132 
Shunya Sugita, Masahito Ohue  (2021)  Drug-target affinity prediction using applicability domain based on data density In Proceedings of The 18th IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB 2021). DOI:10.26434/chemrxiv.14498688.v1
Kota Katayama, Kohei Suzuki, Ryoji Suno, Ryoji Kise, Hirokazu Tsujimoto, So Iwata, Asuka Inoue, Takuya Kobayashi, Hideki Kandori (2021)  Vibrational spectroscopy analysis of ligand efficacy in M2R. Communication Biology. DOI:10.21203/rs.3.rs-411771/v1
Yuichi Aki, Yuta Katsumata, Hirofumi Kakihara, Koichi Nonaka, Kenshu Fujiwara (2021)  4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5- dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture PLoS One. 16 :4,  e0250416- DOI:10.1371/journal.pone.0250416 PMID:33886677 
Satoshi Kamoto, Masahiro Shinada, Daiki Kato, Masaya Tsuboi, Sho Yoshimoto, Ryohei Yoshitake, Shotaro Eto, Namiko Ikeda, Yosuke Takahashi, Yuko Hashimoto, James Chambers, Kazuyuki Uchida, Shinji Yamada, Mika K Kaneko, Ryohei Nishimura, Yukinari Kato, Takayuki Nakagawa (2021)  Expression of podoplanin in various types of feline tumor tissues The Journal of Veterinary Medical Science . DOI:10.1292/jvms.20-0608 PMID:34657899 
Aoze Su, Yuko Tabata, Kiyono Aoki, Akane Sada, Rieko Ohki, Satoru Nagatoishi, Kouhei Tsumoto, Siyuan Wang, Yuko Otani, Tomohiko Ohwada (2021)  Elaboration of non-naturally occurring helical tripeptides as p53-MDM2/MDMX interaction inhibitors Chemical & pharmaceutical bulletin. 69 :7,  681-692 DOI:10.1248/cpb.c21-00238 PMID:33952867 
Kotaro Kasai,?Yuma Horii,Takanori Hironaka,Kyosuke Mae,Tomoyuki Ueno,Akiomi Nagasaka,Michio Nakaya (2021)  Increased Expression of Heparan Sulfate 6-O-Sulfotransferase-2 Promotes Collagen Production in Cardiac Myofibroblasts BPB Reports. 4 :3,  85-91 DOI:10.1248/bpbreports.4.3_85
Takuji Oyama,Shotaro Kamata, Isao Ishii, and Hiroyuki Miyachi (2021)  Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method Biological and Pharmaceutical Bulletin. 44 :9,  1202-1209 DOI:10.1248/bpb.b21-00220 PMID:34471048 
Akihiro Kobayashi, Tsubasa Matsuzawa, Takamitsu Hosoya, and Suguru Yoshida (2021)  Thioxanthone Synthesis from Benzoic Acid Esters through Directed ortho-Lithiation Chemistry Letters. 50 :9,  1624-1627 DOI:10.1246/cl.210293
Tsuneyuki Kobayashi, Takamitsu Hosoya, and Suguru Yoshida (2021)  Facile Synthetic Methods for Diverse N-Arylphenylalanine Derivatives via Transformations of Aryne Intermediates and Cross-Coupling Reactions Bulletin of the Chemical Society of Japan. 94 :7,  1823-1832 DOI:10.1246/bcsj.20210149
Kazuki Watanabe, Chiduru Watanabe, Teruki Honma, Yu-Shi Tian,Yusuke Kawashima, Norihito Kawashita, Kaori Fukuzawa, and Tatsuya Takagi (2021)  Computational ab initio interaction analyses between neutralizing antibody and SARS-CoV-2 variant spike proteins using the fragment molecular orbital method The Chemical Society of Japan. 94 :6,  1794-1798 DOI:10.1246/bcsj.20210104
Yuki Takada, Ruken Yaman-Deveci, Takayuki Shirakawa, Jafar Sharif, Shin-Ichi Tomizawa, Fumihito Miura, Takashi Ito, Michio Ono, Kuniko Nakajima, Yoko Koseki, Fuyuko Shiotani, Kei-Ichiro Ishiguro, Kazuyuki Ohbo, Haruhiko Koseki (2021)  Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing Development. 148 :10,  dev194605- DOI:10.1242/dev.194605 PMID:33998651 
Riku Kawanabe, Kohei Yoshihara, Izuho Hatada, Makoto Tsuda (2021)  Activation of spinal dorsal horn astrocytes by noxious stimuli involves descending noradrenergic signaling Molecular brain. 14 :1,  79- DOI:10.1186/s13041-021-00788-5 PMID:33971918 
Kazuki Matsumura,Takushi Shimomura,Yoshihiro Kubo,Takayuki Oka,Naohiro Kobayashi,Shunsuke Imai,Naomi Yanase,Madoka Akimoto,Masahiro Fukuda,Mariko Yokogawa,Kazuyoshi Ikeda,Jun-Ichi Kurita,Yoshifumi Nishimura,Ichio Shimada,Masanori Osawa (2021)  Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization BMC Mol Cell Biol. 22 :1,  3- DOI:10.1186/s12860-020-00337-3 PMID:33413079 
Kaori Saito , Qi Zhang , Haeun Yang , Kotoko Yamatani , Tomohiko Ai , Vivian Ruvolo , Natalia Baran , Tianyu Cai , Helen Ma , Rodrigo Jacamo , Vinitha Kuruvilla , Junichi Imoto , Sonoko Kinjo , Kazuho Ikeo , Kaori Moriya , Koya Suzuki , Takashi Miida , Yong-Mi Kim , Christopher P Vellano , Michael Andreeff , Joseph R Marszalek , Yoko Tabe , Marina Konopleva (2021)  Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition Blood Advances. 5 DOI:10.1182/bloodadvances.2020003661 PMID:34507353 
Tri Wahyuni, Arisa Kobayashi, Shota Tanaka, Yoshiaki Miyake, Ayaha Yamamoto, Anton Bahtiar, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Kotaro Matsumoto, Makiko Maeda, Masanori Obana, Yasushi Fujio (2021)  Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway Am J Physiology Cell Physiology. 321 :1,  C82-C93 DOI:10.1152/ajpcell.00568.2020 PMID:34038245 
Anqi Zhang, Takafumi Suzuki, Saki Adachi, Eriko Naganuma, Norio Suzuki, Tomonori Hosoya, Ken Itoh, Michael B Sporn, Masayuki Yamamoto (2021)  Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction Molecular Cellular Biology. 41 :11,  e0023621- DOI:10.1128/MCB.00236-21 PMID:34398680 
Atsushi Kawai , Yasuyuki Yamamoto , Takuto Nogimori , Kohei Takeshita , Takuya Yamamoto , Yasuo Yoshioka (2021)  The Potential of Neuraminidase as an Antigen for Nasal Vaccines To Increase Cross-Protection against Influenza Viruses Journal of Virology. 95 :20,  e01180-21- DOI:10.1128/JVI.01180-21 PMID:34379511 
Tracy M Josephs , Matthew J Belousoff , Yi-Lynn Liang , Sarah J Piper , Jianjun Cao , Daniel J Garama , Katie Leach , Karen J Gregory , Arthur Christopoulos , Debbie L Hay , Radostin Danev , Denise Wootten , Patrick M Sexton (2021)  Structure and dynamics of the CGRP receptor in apo and peptide-bound forms Science. 372 :6538,  eabf7258- DOI:10.1126/science.abf7258 PMID:33602864 
Stephanie L Neville , Jennie Sjohamn , Jacinta A Watts , Hugo MacDermott-Opeskin , Stephen J Fairweather , Katherine Ganio , Alex Carey Hulyer , Aaron P McGrath , Andrew J Hayes , Tess R Malcolm , Mark R Davies , Norimichi Nomura , So Iwata , Megan L OMara , Megan J Maher , Christopher A McDevitt (2021)  The structural basis of bacterial manganese import Science Advances. 7 :32,  eabg3980- DOI:10.1126/sciadv.abg3980 PMID:34362732 
Rieko Imae , Naoyuki Kuwabara , Hiroshi Manya , Tomohiro Tanaka , Masato Tsuyuguchi , Mamoru Mizuno , Tamao Endo , Ryuichi Kato (2021)  The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on α-dystroglycan. Genes to Cells . 26 :7,  485-494 DOI:10.1111/gtc.12853 PMID:33893702 
Takayoshi Tagami, Minghao Chen, Yuta Furunaga, Asako Kikuchi, Juri Sadahiro, Weeranuch Lang, Masayuki Okuyama, Yoshikazu Tanaka, Tomohito Iwasaki, Min Yao, Atsuo Kimura (2021)  Structural insights reveal the second base catalyst of isomaltose glucohydrolase The FEBS Journal. DOI:10.1111/febs.16237 PMID:34665923 
Linda Juniar , Vida Adlfar , Michael Hippler , Hideaki Tanaka , Genji Kurisu (2021)  X-ray crystallographic analysis of iron-assimilating protein 1 FEA1 from Chlamydomonas Reinhardtii Acta Crystallographica Section F. 77 134-139 DOI:10.1107/S2053230X21003952 PMID:33949973 
Seiki Baba, Hiroaki Matsuura,Takashi Kawamura,Naoki Sakai, Yuki Nakamura,Yoshiaki Kawano,Nobuhiro Mizuno,Takashi Kumasaka, Masaki Yamamotob and Kunio Hirata (2021)  Guidelines for de novo phasing using multiple small-wedge data collection JOURNAL OF SYNCHROTRON RADIATION. 28 1284-1295 DOI:10.1107/S1600577521008067 PMID:34475278 
Shintaro Minami, Naohiro Kobayashi, Toshihiko Sugiki, Toshio Nagashima, Toshimichi Fujiwara, Rie Koga, George Chikenji, Nobuyasu Koga (2021)  Exploration of novel αβ-protein folds through de novo design bioRxiv. DOI:10.1101/2021.08.06.455475
Shubhi Pandey , Punita Kumari , Mithu Baidya , Ryoji Kise , Yubo Cao , Hemlata Dwivedi-Agnihotri , Ramanuj Banerjee , Xaria X Li , Cedric S Cui , John D Lee , Kouki Kawakami , Jagannath Maharana , Ashutosh Ranjan , Madhu Chaturvedi , Gagan Deep Jhingan , Stephane A Laporte , Trent M Woodruff , Asuka Inoue , Arun K Shukla (2021)  Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Mol Cell. 81 :22,  4605-4621 DOI:10.1016/j.molcel.2021.09.007 PMID:34582793  
Shoko Sato, Yoshimasa Takizawa, Fumika Hoshikawa, Mariko Dacher, Hiroki Tanaka, Hiroaki Tachiwana, Tomoya Kujirai, Yukari Iikura, Cheng-Han Ho, Naruhiko Adachi, Indu Patwal, Andrew Flaus, Hitoshi Kurumizaka  (2021)  Cryo-EM structure of the nucleosome core particle containing Giardia lamblia histone Nucleic Acids Research. 49 :15,  8934-8946 DOI:10.1093/nar/gkab644 PMID:34352093 
Natsu Nakajima, Tomoatsu Hayashi, Katsunori Fujiki, Katsuhiko Shirahige, Tetsu Akiyama, Tatsuya Akutsu, Ryuichiro Nakato (2021)  Codependency and mutual exclusivity for gene community detection from sparse single-cell transcriptome data Nucleic Acids research. 49 :18,  e104- DOI:10.1093/nar/gkab601 PMID:34291282 
Keisuke Oki, Takeshi Yamagami, Mariko Nagata, Kouta Mayanagi, Tsuyoshi Shirai, Naruhiko Adachi, Tomoyuki Numata, Sonoko Ishino,Yoshizumi Ishino (2021)  DNA polymerase D temporarily connects primase to the CMG-like helicase before interacting with proliferating cell nuclear antigen Nucleic Acids Res. 49 :8,  4599-4612 DOI:10.1093/nar/gkab243 PMID:33849056 
Yoshihiro Kobashigawa , Toshiya Ohara , Kosuke Morita, Yuya Toyota , Teruya Nakamura, Shunsuke Kotani, Takao Arimori , Soichiro Yamauchi , Chenjiang Liu , Masaya Kitazaki , Yukari Wakeyama-Miyazaki , Yoshiaki Suwa , Makiyo Uchida-Kamekura , Natsuki Fukuda , Takashi Sato , Makoto Nakajima , Junichi Takagi , Yuriko Yamagata , Hiroshi Morioka (2021)  Molecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues Journal of Biochemistry. DOI:10.1093/jb/mvab056 PMID:34185078 
Nobuhiro Sato , Rina Yogo , Saeko Yanaka, Anne Martel , Lionel Porcar , Ken Morishima , Rintaro Inoue , Taiki Tominaga , Takao Arimori , Junichi Takagi , Masaaki Sugiyama , Koichi Kato (2021)  A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems. Journal of biochemistry. 169 :6,  701-708 DOI:10.1093/jb/mvab012 PMID:33585933 
Chie Motono, Shunsuke Yanagida, Miwa Sato, Takatsugu Hirokawa (2021)  MDContactCom: a tool to identify differences of protein molecular dynamics from two MD simulation trajectories in terms of interresidue contacts Bioinformatics. DOI:10.1093/bioinformatics/btab538 PMID:34289011 
Nami Tateyama, Teizo Asano, Tomokazu Ohishi, Junko Takei, Hideki Hosono, Ren Nanamiya, Tomohiro Tanaka, Masato Sano, Masaki Saito, Manabu Kawada, Mika K. Kaneko, and Yukinari Kato (2021)  An Anti-HER2 Monoclonal Antibody H2Mab-41 Exerts Antitumor Activities in Mouse Xenograft Model Using Dog HER2-Overexpressed Cells MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY. 40 :4,  184-190 DOI:10.1089/mab.2021.0025 PMID:34424760 
Teizo Asano , Mika K Kaneko , Yukinari Kato (2021)  Development of a Novel Epitope Mapping System: RIEDL Insertion for Epitope Mapping Method. Monoclon. Antib. Immunodiagn. Immunother.. 40 :4,  162-167 DOI:10.1089/mab.2021.0023 PMID:34424761 
Junko Takei, Teizo Asano, Tomohiro Tanaka, Masato Sano, Hideki Hosono, Ren Nanamiya, Nami Tateyama, Masaki Saito, Hiroyoshi Suzuki, Hiroyuki Harada, Mika K Kaneko, Yukinari Kato (2021)  Development of a Novel Anti-HER2 Monoclonal Antibody H2Mab-181 for Gastric Cancer MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY. 40 :4,  168-176 DOI:10.1089/mab.2021.0021 PMID:34424764 
Ren Nanamiya , Junko Takei , Teizo Asano , Masato Sano , Tomohiro Tanaka , Hideki Hosono , Hiroyuki Harada , Yusuke Sakai , Takuya Mizuno , Hiroyoshi Suzuki , Mika K Kaneko , Yukinari Kato (2021)  Ferret Podoplanin Is Detected by PMab-241 in Immunohistochemistry. MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY. 40 :3,  101-106 DOI:10.1089/mab.2021.0016 PMID:34161160 
Hideki Hosono, Teizo Asano, Junko Takei, Masato Sano, Tomohiro Tanaka, Mika K. Kaneko, and Yukinari Kato (2021)  Development of an Anti-Elephant Podoplanin Monoclonal Antibody PMab-265 for Flow Cytometry MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY. 40 :3,  141-145 DOI:10.1089/mab.2021.0015 PMID:34042502 
Masato Sano , Mika K Kaneko , Teizo Aasano , Yukinari Kato (2021)  Epitope Mapping of an Antihuman EGFR Monoclonal Antibody (EMab-134) Using the REMAP Method MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY. 40 :4,  191-195 DOI:10.1089/mab.2021.0014 PMID:34283639 
Teizo Asano , Mika K Kaneko , Junko Takei , Nami Tateyama , Yukinari Kato (2021)  Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C 44 Mab-46) Using the REMAP Method Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :4,  156-161 DOI:10.1089/mab.2021.0012 PMID:34283655 
Tomohiro Tanaka, Teizo Asano, Masato Sano, Junko Takei, Hideki Hosono, Ren Nanamiya, Takuro Nakamura, Miyuki Yanaka, Hiroyuki Harada, Masato Fukui, Hiroyoshi Suzuki, Kazuyuki Uchida,Takayuki Nakagawa, Yukinari Kato, and Mika K. Kaneko (2021)  Development of Monoclonal Antibody PMab-269 Against California Sea Lion Podoplanin MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY. 40 :3,  124-133 DOI:10.1089/mab.2021.0011 PMID:34042540 
Ren Nanamiya, Masato Sano, Teizo Asano, Miyuki Yanaka, Takuro Nakamura, Masaki Saito, Tomohiro Tanaka, Hideki Hosono, Nami Tateyama, Mika K Kaneko, Yukinari Kato (2021)  Epitope Mapping of an Anti-Human Epidermal Growth Factor Receptor Monoclonal Antibody (EMab-51) Using the RIEDL Insertion for Epitope Mapping Method MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY. 40 :4,  149-155 DOI:10.1089/mab.2021.0010 PMID:34424763 
Teizo Asano,Ren Nanamiya,Junko Takei,Takuro Nakamura,Miyuki Yanaka,Hideki Hosono,Tomohiro Tanaka,Masato Sano,Mika K Kaneko,Yukinari Kato (2021)  Development of Anti-Mouse CC Chemokine Receptor 3 Monoclonal Antibodies for Flow Cytometry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 40 :3,  107-112 DOI:10.1089/mab.2021.0009 PMID:33877898 
Ren Nanamiya , Junko Takei , Teizo Asano , Tomohiro Tanaka , Masato Sano , Takuro Nakamura , Miyuki Yanaka , Hideki Hosono , Mika K Kaneko , Yukinari Kato (2021)  Development of Anti-Human CC Chemokine Receptor 9 Monoclonal Antibodies for Flow Cytometry Monoclon Antib Immunodiagn Immunother. 40 :3,  101-106 DOI:10.1089/mab.2021.0007 PMID:34161159 
Junko Takei, Teizo Asano, Ren Nanamiya, Takuro Nakamura, Miyuki Yanaka, Hideki Hosono, Tomohiro Tanaka, Masato Sano, Mika K. Kaneko, Hiroyuki Harada, and Yukinari Kato (2021)  Development of Anti-human T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Monoclonal Antibodies for Flow Cytometry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 40 :2,  71-75 DOI:10.1089/mab.2021.0006 PMID:33900817 
Tomohiro Tanaka , Ren Nanamiya , Junko Takei , Takuro Nakamura , Miyuki Yanaka , Hideki Hosono , Masato Sano , Teizo Asano , Mika K Kaneko , Yukinari Kato (2021)  Development of Anti-Mouse CC Chemokine Receptor 8 Monoclonal Antibodies for Flow Cytometry. MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY. 40 :2,  65-70 DOI:10.1089/mab.2021.0005 PMID:33900818 
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu  (2021)  UDP-glucuronosyltransferase 1A4-mediated N2- glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised livers Xenobiotica. 51 :10,  1146-1154 DOI:10.1080/00498254.2021.1972492 PMID:34423713 
Genki Minegishi, Yasuhiro Kazuki, Shin-Ichiro Nitta, Atsushi Miyajima, Hidetaka Akita, Kaoru Kobayashi (2021)  In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3Ahumanised mice Xenobiotica. 51 :7,  764-770 DOI:10.1080/00498254.2021.1921314 PMID:34013847 
Takuto Kumano, Sanae Hori, Satomi Watanabe, Yuzu Terashita, Hong Yang Yu, Yoshiteru Hashimoto, Toshiya Senda, Miki Senda, Michihiko Kobayashi (2021)  Novel FAD-dependent C-glycoside-metabolizing Enzymes in Microorganisms: Screening, Characterization and Crystal Structure Analysis Proc Natl Acad Sci U S A. 118 :40,  e2106580118- DOI:10.1073/pnas.2106580118 PMID:34583991 
Simon Miller , Ashutosh Srivastava , Yoshiko Nagai , Yoshiki Aikawa , Florence Tama , Tsuyoshi Hirota  (2021)  Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation Proc Natl Acad Sci USA. 118 :26,  e2026191118- DOI:10.1073/pnas.2026191118 PMID:34172584 
Atsushi Kimishima, Hayato Saito, Violeta Petrova, Masayoshi Arai (2021)  Asymmetric Formal Synthesis of Trichodermamides B and C Synlett. 32 :18,  1865-1868 DOI:10.1055/s-0040-1720383
Naoki Kamo, Tomoya Kujirai, Hitoshi Kurumizaka, Hiroshi Murakami, Gosuke Hayashi and Akimitsu Okamoto  (2021)  Organoruthenium-catalyzed chemical protein synthesis to elucidate the functions of epigenetic modifications on heterochromatin factors. Chemical Science. 12 :16,  5926-5937 DOI:10.1039/D1SC00731A
Yuki Wada, Toshiki Akiyama, Kazuo Harada,Tetsuo Honma Hiroshi Naka, Susumu Saito and Mitsuiro Arisawa (2021)  Preparation of a platinum nanoparticle catalyst located near photocatalyst titanium oxide and its catalytic activity to convert benzyl alcohols to the corresponding ethers RSC Advances. 11 :36,  22230-22237 DOI:10.1039/d1ra00988e
Yue Ma , Yuki Wakabayashi , Naruyuki Watatani , Ryota Saito , Takatsugu Hirokawa , Masayuki Tera , Kazuo Nagasawa  (2021)  Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand Organic and Biomolecular Chemistry. 19 :37,  8035-8040 DOI:10.1039/d1ob01500a PMID:34492672 
Masatoshi Shibuya , Takayuki Orihashi , Yamei Li , Yoshihiko Yamamoto (2021)  N-Hydroxyphthalimide-catalyzed chemoselective intermolecular benzylic C-H amination of unprotected arylalkanols Chemical Communications. 57 :70,  8742-8745 DOI:10.1039/d1cc03466a PMID:34374398 
Junya Obata , Norifumi Kawakami , Akihisa Tsutsumi , Erika Nasu , Kenji Miyamoto , Masahide Kikkawa , Ryoichi Arai  (2021)  Icosahedral 60-meric porous structure of designed supramolecular protein nanoparticle TIP60 Chemical Communications. 57 :79,  10226-10229 DOI:10.1039/d1cc03114g PMID:34523636 
Kanako Nozawa-Kumada , Yuta Matsuzawa , Kanako Ono , Masanori Shigeno , Yoshinori Kondo (2021)  Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones Chemical Communications. 57 :69,  8604-8607 DOI:10.1039/d1cc02870g PMID:34368822 
Joseph M Rogers , Mickal Nawatha , Betsegaw Lemma , Ganga B Vamisetti , Ido Livneh , Uri Barash, Israel Vlodavsky , Aaron Ciechanover , David Fushman , Hiroaki Suga , Ashraf Brik  (2021)  In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides RSC Chemical Biology. 2 :2,  513-522 DOI:10.1039/d0cb00179a PMID:34179781 
Akinobu Senoo, Sho Ito, Satoru Nagatoishi, Yutaro Saito, Go Ueno, Daisuke Kuroda, Kouhei Yoshida, Takumi Tashima, Shota Kudo, Shinsuke Sando & Kouhei Tsumoto (2021)  Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion Communications Biology. 4 :1,  1041- DOI:10.1038/s42003-021-02575-3 PMID:34493804 
Yumi Inoue , Miki Kinoshita , Mamoru Kida , Norihiro Takekawa , Keiichi Namba , Katsumi Imada , Tohru Minamino  (2021)  The FlhA linker mediates flagellar protein export switching during flagellar assembly. Communications biology. 4 :1,  646- DOI:10.1038/s42003-021-02177-z PMID:34059784 
Miki Kinoshita , Keiichi Namba , Tohru Minamino (2021)  A positive charge region of Salmonella FliI is required for ATPase formation and efficient flagellar protein export. Communications biology. 4 :1,  464- DOI:10.1038/s42003-021-01980-y PMID:33846530 
Keiko Fukasawa , Mari Gotoh , Akiharu Uwamizu , Takatsugu Hirokawa , Masaki Ishikawa , Yoshibumi Shimizu , Shinji Yamamoto , Kensuke Iwasa , Keisuke Yoshikawa , Junken Aoki , Kimiko Murakami-Murofushi  (2021)  2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition Scientific Reports. 11 :1,  17360- DOI:10.1038/s41598-021-96931-2 PMID:34462512 
Moe Ichikawa, Hiroki Akamine, Michika Murata, Sumito Ito, Kazuo Takayama, Hiroyuki Mizuguchi (2021)  Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system Scientific Reports. 11 :1,  11670- DOI:10.1038/s41598-021-91160-z PMID:34083621 
Melissa M Matthews , Tae Gyun Kim , Satoshi Shibata , Noriko Shibata , Christian Butcher , Jaekyung Hyun , Keon Young Kim , Theodore Robb , Siang Sheng Jheng , Masashi Narita , Tomoari Mori , Mary Collins , Matthias Wolf  (2021)  COVID-19 serological survey using micro blood sampling Scientific Reports. 11 :1,  9475- DOI:10.1038/s41598-021-88850-z PMID:33947894 
Akihiro Nakamura , Yoshiyuki Suzuki , Yasumitsu Sakamoto , Saori Roppongi , Chisato Kushibiki , Natsuri Yonezawa , Masato Takahashi , Yosuke Shida , Hiroaki Gouda , Takamasa Nonaka , Nobutada Tanaka , Wataru Ogasawara (2021)  Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7 Scientific Reports. 11 :1,  7929- DOI:10.1038/s41598-021-86965-x PMID:33846449 
Christopher J Draper-Joyce , Rebecca Bhola , Jinan Wang , Apurba Bhattarai , Anh T N Nguyen , India Cowie-Kent , Kelly O'Sullivan , Ling Yeong Chia , Hariprasad Venugopal , Celine Valant , David M Thal , Denise Wootten , Nicolas Panel , Jens Carlsson , Macdonald J Christie , Paul J White , Peter Scammells , Lauren T May , Patrick M Sexton , Radostin Danev , Yinglong Miao , Alisa Glukhova , Wendy L Imlach , Arthur Christopoulos  (2021)  Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia Nature. 597 :7877,  571-576 DOI:10.1038/s41586-021-03897-2 PMID:34497422 
Kazuhiro Abe,Kenta Yamamoto,Katsumasa Irie,Tomohiro Nishizawa,Atsunori Oshima  (2021)  Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations Nature Communications. 12 :1,  5709- DOI:10.1038/s41467-021-26024-1 PMID:34588453 
Agata Butryn , Philipp S Simon , Pierre Aller , Philip Hinchliffe , Ramzi N Massad , Gabriel Leen , Catherine L Tooke , Isabel Bogacz , In-Sik Kim , Asmit Bhowmick , Aaron S Brewster , Nicholas E Devenish , J?rgen Brem , Jos J A G Kamps , Pauline A Lang , Patrick Rabe , Danny Axford , John H Beale , Bradley Davy , Ali Ebrahim , Julien Orlans , Selina L S Storm , Tiankun Zhou , Shigeki Owada , Rie Tanaka , Kensuke Tono , Gwyndaf Evans , Robin L Owen , Frances A Houle , Nicholas K Sauter , Christopher J Schofield , James Spencer , Vittal K Yachandra , Junko Yano , Jan F Kern , Allen M Orville  (2021)  An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography Nature Communications. 12 :1,  4461- DOI:10.1038/s41467-021-24757-7 PMID:34294694 
Masahiko Ajiro , Tomonari Awaya , Young Jin Kim , Kei Iida , Masatsugu Denawa , Nobuo Tanaka , Ryo Kurosawa , Shingo Matsushima , Saiko Shibata , Tetsunori Sakamoto , Lorenz Studer , Adrian R Krainer , Masatoshi Hagiwara (2021)  Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. Nature Communications. 12 :1,  4507- DOI:10.1038/s41467-021-24705-5 PMID:34301951 
Akihiro Kawamoto , Tomoko Miyata , Fumiaki Makino , Miki Kinoshita , Tohru Minamino , Katsumi Imada , Takayuki Kato , Keiichi Namba (2021)  Native flagellar MS ring is formed by 34 subunits with 23-fold and 11-fold subsymmetries Nature Communications. 12 :1,  4223- DOI:10.1038/s41467-021-24507-9 PMID:34244518 
Kazunari Sakai , Masato Iwatsuki , Taichi Kaneta , Aoi Kimishima , Yukihiro Asami , Toshiaki Sunazuka , Rokuro Masuma , Kenichi Nonaka (2021)  Sesquicillin F, a new insecticidal meroterpenoid produced by Mariannaea macrochlamydospora FKI-4735 by Mariannaea macrochlamydospora FKI-4735 The Journal of Antibiotics. 74 :11,  817-820 DOI:10.1038/s41429-021-00456-9 PMID:34334788 
Hiroaki Ikeda , Hideaki Kakeya (2021)  Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapy The Journal of Antibiotics. 74 :10,  687-695 DOI:10.1038/s41429-021-00451-0 PMID:34331027 
Akihiro Eguchi, Ayaka Ueki, Junya Hoshiyama, Keiko Kuwata, Yoko Chikaoka, Takeshi Kawamura, Satoru Nagatoishi, Kouhei Tsumoto, Ryosuke Ueki, and Shinsuke Sando (2021)  A DNA Aptamer That Inhibits the Aberrant Signaling of Fibroblast Growth Factor Receptor in Cancer Cells JACS Au. 1 :5,  578-585 DOI:10.1021/jacsau.0c00121 PMID:34467321 
Yuta Sato, Naoko Oyobe, Takao Ogawa, Sayo Suzuki, Hiroshi Aoyama, Tomonori Nakamura, Hiromichi Fujioka, Satoshi Shuto, and Mitsuhiro Arisawa (2021)  Design, Synthesis, and Monoamine Oxidase Inhibitory Activity of (+)-Cinchonaminone and Its Simplified Derivatives ACS medicinal chemistry letters. 12 :9,  1464-1469 DOI:10.1021/acsmedchemlett.1c00310 PMID:34531955 
Ryo Tashiro,Takaaki Sato,Haruyuki Atomi,Kunio Miki,Masahiro Fujihashi (2021)  Altering the Phosphorylation Position of Pyrophosphate-Dependent myo-Inositol-1-Kinase Based on Its Crystal Structure ACS Chemical Biology. 16 :5,  794-799 DOI:10.1021/acschembio.0c00733 PMID:33877806 
Takeshi Yasui, Keiji Yamada, Rine Tatsumi, and Yoshihiko Yamamoto (2021)  Cobalt/Organophotoredox Dual-Catalysis-Enabled Cascade Cyclization of 1,6-Diynyl Esters via Formal 1,8-Acyloxy Migration ACS Catalysis. 11 :18,  11716-11722 DOI:10.1021/acscatal.1c03704
Takeshi Yasui, Rine Tatsumi, and Yoshihiko Yamamoto (2021)  Highly Enantioselective [2+2+2] Cycloaddition of Enediynes Enabled by Cobalt/Organophotoredox Cooperative Catalysis ACS Catalysis. 11 :15,  9479-9484 DOI:10.1021/acscatal.1c02410
Takefumi Kuranaga, Miho Tamura, Hiroaki Ikeda, Sakahiro Terada, Yusuke Nakagawa, and Hideaki Kakeya (2021)  Identification and Total Synthesis of an Unstable Anticancer Macrolide Presaccharothriolide Z Produced by Saccharothrix sp. A1506 Organic Letters. 23 :18,  7106-7111 DOI:10.1021/acs.orglett.1c02506 PMID:34436915 
Kanako Nozawa-Kumada, Koto Noguchi, Tomoya Akada, Masanori Shigeno, and Yoshinori Kondo (2021)  Regio- and Stereoselective Hydroiodination of Internal Alkynes with Ex Situ-Generated HI Organic Letters. 23 :17,  6659-6663 DOI:10.1021/acs.orglett.1c02218 PMID:34474572 
Tomohiro Kikuchi, Keiji Yamada, Takeshi Yasui, Yoshihiko Yamamoto (2021)  Synthesis of Benzo-Fused Cyclic Ketones via Metal-Free Ring Expansion of Cyclopropanols Enabled by Proton-Coupled Electron Transfer Organic Letters. 23 :12,  4710-4714 DOI:10.1021/acs.orglett.1c01436 PMID:34060855 
Takehiro Nishimura, Teppei Kawahara, Noritaka Kagaya, Yusuke Ogura, Hirosato Takikawa, Hikaru Suenaga, Masaatsu Adachi, Takatsugu Hirokawa, Takayuki Doi, Kazuo Shin-Ya (2021)  JBIR-155, a Specific Class D β-Lactamase Inhibitor of Microbial Origin Organic letters. 23 :11,  4415-4419 DOI:10.1021/acs.orglett.1c01352 PMID:34029112 
Minori Suzuki, Kazuya Kanemoto, Yu Nakamura, Takamitsu Hosoya, Suguru Yoshida (2021)  Palladium-Catalyzed Sulfinylation of Aryl- and Alkenylborons with Sulfinate Esters Organic Letters. 23 :9,  3796-3737 DOI:10.1021/acs.orglett.1c01292 PMID:33908784 
Jiawei Qiu, Makoto Sako, Tomoyuki Tanaka, Tsuyoshi Matsuzaki, Tsunayoshi Takehara, Takeyuki Suzuki, Shohei Ohno, Kenichi Murai, and Mitsuhiro Arisawa (2021)  Iridium-Catalyzed Isomerization/Cycloisomerization/Aromatization of N-Allyl-N-sulfonyl-o-(λ1 -silylethynyl)aniline Derivatives to Give Substituted Indole Derivatives Organic Letters. 23 :11,  4284-4288 DOI:10.1021/acs.orglett.1c01231 PMID:34032456 
Tetsuya Kadota, Masanao Sawa, Yuta Kondo, Hiroyuki Morimoto, Takashi Ohshima (2021)  Catalytic Enantioselective Strecker Reaction of Isatin-Derived N-Unsubstituted Ketimines Organic Letters. 23 :12,  4553-4558 DOI:10.1021/acs.orglett.1c0119423 PMID:34029103 
Yuki Wada, Tsunayoshi Takehara, Takeyuki Suzuki, Satoshi Aoki, Takayuki Hibi, Makoto Sako, Hirofumi Tsujino, Yasuo Tsutsumi, and Mitsuhiro Arisawa (2021)  Carbon-Carbon Bond Formation between N-Heterocyclic Carbene Ligand on Ruthenium Carbene Catalysts and 1,4-Naphthoquinone via Intramolecular Carbon(sp3)-Hydrogen Bond Activation Organometallics. 40 :16,  2901-2908 DOI:10.1021/acs.organomet.1c00350
Kazuki Watanabe , Chiduru Watanabe , Teruki Honma , Yu-Shi Tian , Yusuke Kawashima , Norihito Kawashita , Tatsuya Takagi , Kaori Fukuzawa  (2021)  Intermolecular Interaction Analyses on SARS-CoV-2 Receptor Binding Domain and Human Angiotensin-Converting Enzyme 2 Receptor-Blocking Antibody/peptide Using Fragment Molecular Orbital Calculation. The Journal of Physical Chemistry Letters. 12 :16,  4059-4066 DOI:10.1021/acs.jpclett.1c00663 PMID:33881894 
Miku Kimura, Tomoyo Mohri, Masaru Enomoto, Yasuhiro Meguro, Yusuke Ogura, and Shigefumi Kuwahara (2021)  Seven-Step Total Synthesis of Sporothriolide The Journal of Organic Chemistry. 86 :17,  12475-12479 DOI:10.1021/acs.joc.1c01663 PMID:34423986 
Kenji Watanabe, Nodoka Terao, Takashi Niwa, and Takamitsu Hosoya (2021)  Direct 3-Acylation of Indolizines by Carboxylic Acids for the Practical Synthesis of Red Light-Releasable Caged Carboxylic Acids The Journal of Organic Chemistry. 86 :17,  11822-11834 DOI:10.1021/acs.joc.1c01244 PMID:34279948 
Hayate Kinouchi , Kazuma Sugimoto , Yousuke Yamaoka , Hiroshi Takikawa , Kiyosei Takasu (2021)  Oxidative β-Cleavage of Fused Cyclobutanols Leading to Hydrofuran-Fused Polycyclic Aromatic Compounds The Journal of Organic Chemistry. 86 :18,  12615-12622 DOI:10.1021/acs.joc.1c01108 PMID:34474562 
Shota Nagasawa, Shogo Fujiki, Yusuke Sasano, Yoshiharu Iwabuchi (2021)  Chromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols The Journal of organic chemistry. 86 :9,  6952-6968 DOI:10.1021/acs.joc.1c00438 PMID:33890777 
Mitsuyasu Kawaguchi, Eriko Sekimoto, Yuhei Ohta, Naoya Ieda, Takashi Murakami, and Hidehiko Nakagawa (2021)  Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors Journal of Medicinal Chemistry. 64 :13,  9567-9576 DOI:10.1021/acs.jmedchem.1c00874 PMID:34160227 
Sho Konno , Kiyotaka Kobayashi , Miki Senda , Yuta Funai , Yuta Seki , Ikumi Tamai, Laura Schakel , Kyousuke Sakata , Thanigaimalai Pillaiyar , Akihiro Taguchi , Atsuhiko Taniguchi , Michael Gutschow , Christa E M?ller , Koh Takeuchi , Mikako Hirohama , Atsushi Kawaguchi , Masaki Kojima , Toshiya Senda , Yoshiyuki Shirasaka , Wataru Kamitani , Yoshio Hayashi (2021)  3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents Journal of Medicinal Chemistry. DOI:10.1021/acs.jmedchem.1c00665 PMID:34313428 
Misa Sayama , Akiharu Uwamizu , Masaya Ikubo , Luying Chen , Ge Yan , Yuko Otani, Asuka Inoue , Junken Aoki , Tomohiko Ohwada (2021)  Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine Journal of Medicinal Chemistry. 64 :14,  10059-10101 DOI:10.1021/acs.jmedchem.1c00347 PMID:34233115 
Toru Ekimoto , Takafumi Kudo , Tsutomu Yamane , Mitsunori Ikeguchi (2021)  Mechanism of Vitamin D Receptor Ligand-Binding Domain Regulation Studied by gREST Simulations Journal of Chemical Information and Modeling. 61 :7,  3625-3637 DOI:10.1021/acs.jcim.1c0053 PMID:34189910 
Kei Takedomi , Masateru Ohta , Toru Ekimoto , Mitsunori Ikeguchi (2021)  Effect of Water Molecules on the Activating S810L Mutation of the Mineralocorticoid Receptor Journal of Chemical Information and Modeling. 61 :7,  3583-3592 DOI:10.1021/acs.jcim.1c00389 PMID:34228431 
Kei Moritsugu, Koh Takeuchi, Narutoshi Kamiya, Junichi Higo, Isao Yasumatsu, Yoshifumi Fukunishi and Ikuo Fukuda (2021)  Flexibility and Cell Permeability of Cyclic Ras-Inhibitor Peptides Revealed by the Coupled Nose-Hoover Equation Journal of Chemical Information and Modeling. 61 :4,  1921-1930 DOI:10.1021/acs.jcim.0c01427 PMID:33835817 
Daisuke Takaya , Chiduru Watanabe , Shunpei Nagase , Kikuko Kamisaka , Yoshio Okiyama , Hirotomo Moriwaki , Hitomi Yuki, Tomohiro Sato , Noriyuki Kurita , Yoichiro Yagi , Tatsuya Takagi , Norihito Kawashita , Kenichiro Takaba , Tomonaga Ozawa , Midori Takimoto-Kamimura , Shigenori Tanaka , Kaori Fukuzawa , Teruki Honma  (2021)  FMODB: The World's First Database of Quantum Mechanical Calculations for Biomacromolecules Based on the Fragment Molecular Orbital Method. J Chem Inf Model. 61 :2,  777-794 DOI:10.1021/acs.jcim.0c01062 PMID:33511845 
Kazutoshi Tani, Ryo Kanno, Xuan-Cheng Ji, Malgorzata Hall, Long-Jiang Yu, Yukihiro Kimura, Michael T Madigan, Akira Mizoguchi, Bruno M Humbel, Zheng-Yu Wang-Otomo (2021)  Cryo-EM Structure of the Photosynthetic LH1-RC Complex from Rhodospirillum rubrum Biochemistry. 60 :32,  2483-2491 DOI:10.1021/acs.biochem.1c00360 PMID:34323477 
Yuki Goto, Hiroaki Suga (2021)  The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides Accounts of chemical research. 54 :18,  3604-3617 DOI:10.1021/acs.accounts.1c00391 PMID:34505781 
Chieko Inoue, Ryosuke Negoro, Kazuo Takayama, Hiroyuki Mizuguchi, Fuminori Sakurai (2021)  Asymmetric profiles of infection and innate immunological responses in human iPS cellderived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus Virus Research. 296 198334- DOI:10.1016/j.virusres.2021.198334 PMID:33581186 
Shinji Tanaka, Sho Yoshinaka, Kiyoshi Kawamura, Mikio Morita, Masato Kitamura (2021)  Systematic asymmetric analog synthesis of fluspidine, a σ1 receptor ligand, to improve ligand affinity Tetrahedron Letters. DOI:10.1016/j.tetlet.2021.153250
Shu Takahashia, Aoi Kimishima, Tomoyasu Hirose, Takeshi Yamada, Akihiro Sugawara, Tatsuya Shirahata, Yoshihiko Noguchi, Masato Iwatsuki, Rei Hokari, AkiI shiyama, Yoshinori Kobayashi, Toshiaki Sunazuka (2021)  Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C Tetrahedron Letters. 67 152895- DOI:10.1016/j.tetlet.2021.152895
Minami Otsubo, KousukeS akimoto, Hiromichi Egami, Yoshitaka Hamashima (2021)  Dearomative enantio- and diastereoselective difluorination of resorcinol derivatives Tetrahedron. 96 132355- DOI:10.1016/j.tet.2021.132355
Xin Zhang,Rachel M Johnson,eva Drulyte,Lingbo Yu,Abhay Kotecha,Radostin Danev,Denise Wootten,Patrick M Sexton,Matthew J Belousoff (2021)  Evolving cryo-EM structural approaches for GPCR drug discovery Structure. 29 :9,  963-974 DOI:10.1016/j.str.2021.04.008 PMID:33957078 
Melissa Carrillo , Suraj Pandey , Juan Sanchez , Moraima Noda , Ishwor Poudyal , Luis Aldama , Tek Narsingh Malla , Elin Claesson , Weixiao Yuan Wahlgren , Denisse Feliz , Vukica Srajer , Michal Maj , Leticia Castillon , So Iwata , Eriko Nango , Rie Tanaka , Tomoyuki Tanaka , Luo Fangjia , Kensuke Tono , Shigeki Owada , Sebastian Westenhoff , Emina A Stojkovic , Marius Schmidt  (2021)  High-resolution crystal structures of transient intermediates in the phytochrome photocycle Structure. 29 :7,  743-754 DOI:10.1016/j.str.2021.03.004 PMID:33756101 
Kaori Fukuzawa, Shigenori Tanaka (2021)  Fragment molecular orbital calculations for biomolecules Current Opinion in Structural Biology. 72 127-134 DOI:10.1016/j.sbi.2021.08.010 PMID:34656048 
Akihito Harada , Hiroshi Kimura , Yasuyuki Ohkawa  (2021)  Recent advance in single-cell epigenomics Current Opinion in Structural Biology. 71 :116,  122- DOI:10.1016/j.sbi.2021.06.010 PMID:34303078 
Amarjeet Kumar , Justin Chan , Masahiko Taguchi , Hidetoshi Kono (2021)  Interplay between nucleosomes and transacting factors around promoter Current Opinion in Structural Biology. 71 7-15 DOI:10.1016/j.sbi.2021.04.008 PMID:34111671 
Nobuaki Yasuo, Takashi Ishida, Masakazu Sekijima (2021)  Computer aided drug discovery review for infectious diseases with case study of anti-Chagas project Parasitology International. 83 :102366,  DOI:10.1016/j.parint.2021.102366 PMID:33915269 
Tomoki Yamashita, Tatsuya Inui, Jumpei Yokota, Kentaro Kawakami, Gaku Morinaga, Masahito Takatani, Daisuke Hirayama, Ryuga Nomoto, Kohei Ito, Yunhai Cui, Stephanie Ruez, Kazuo Harada, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi (2021)  Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research Molecular Therapy: Methods & Clinical Development. 22 263-278 DOI:10.1016/j.omtm.2021.05.005 PMID:34485610 
Naruhiko Adachi, Takahide Yamaguchi, Toshio Moriya, Masato Kawasaki, Kotaro Koiwai, Akira Shinoda, Yusuke Yamada, Fumiaki Yumoto, Takamitsu Kohzuma, Toshiya Senda (2021)  2.85 and 2.99A resolution structures of 110 kDa nitrite reductase determined by 200 kV cryogenic electron microscopy Journal of Structural Biology. 213 :3,  107768- DOI:10.1016/j.jsb.2021.107768 PMID:34217801 
Keito Hiragi , Kazuya Nishio , Shu Moriyama , Tasuku Hamaguchi , Akira Mizoguchi , Koji Yonekura , Kazutoshi Tani , Tsunehiro Mizushima (2021)  Structural insights into the targeting specificity of ubiquitin ligase for S. cerevisiae isocitrate lyase but not C. albicans isocitrate lyase Jounral of Structural Biology. 213 :3,  107748- DOI:10.1016/j.jsb.2021.107748 PMID:34033899 
Kosuke Shido , Kaname Kojima , Matsuyuki Shirota , Kenshi Yamasak , Ikuko N Motoike , Atsushi Hozawa , Soichi Ogishima , Naoko Minegishi , Kozo Tanno , Fumiki Katsuoka, Gen Tamiya , Setsuya Aiba, Masayuki Yamamoto , Kengo Kinoshita  (2021)  GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals Journal of Investigative Dermatology. S0022-202X :21,  1151-9- DOI:10.1016/j.jid.2021.02.762 PMID:33864772 
Yasuhisa Kamikaseda, Takehito Uruno, Kazufumi Kunimura, Akihito Harada, Kuniko Saiki, Kounosuke Oisaki, Daiji Sakata, Takeshi Nakahara, Makiko Kido-Nakahara, Motomu Kanai, Seiji Nakamura, Yasuyuki Ohkawa, Masutaka Furue, Yoshinori Fukui (2021)  Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound The Journal of Allergy and Clinical Immunology. 148 :2,  633-638 DOI:10.1016/j.jaci.2021.03.029 PMID:33819507 
Yasuhiro Isogai, Hiroshi Imamura, Setsu Nakae, Tomonari Sumi, Ken-ichi Takahashi,Tsuyoshi Shirai  (2021)  Common and unique strategies of myoglobin evolution for deep sea adaptation of diving mammals iscience. 24 :8,  102920- DOI:10.1016/j.isci.2021.102920 PMID:34430810 
Katsuya Ohbuchi,Takatsugu Hirokawa (2021)  Protein druggability assessment for natural products using in silico simulation: A case study with estrogen receptor and the flavonoid genistein gene. 791 145726- DOI:10.1016/j.gene.2021.145726 PMID:34010704 
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu (2021)  Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 inchimeric NOG-TKm30 mice transplanted with human hepatocytes Drug Metabolism and Pharmacokinetics. 41 100419- DOI:10.1016/j.dmpk.2021.100419 PMID:34624627 
Chikako Shibazaki, Tomoyuki Ohe, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino (2021)  Development of fluorescent-labeled trapping reagents based on cysteine to detect soft and hard electrophilic reactive metabolites Drug Metabolism and Pharmacokinetics. 39 100386- DOI:10.1016/j.dmpk.2021.100386 PMID:34091122 
Yu Yamamori, Kentaro Tomii (2021)  An ensemble reweighting method for combining the information of experiments and simulations Chemical Physics Letters. 779 138821- DOI:10.1016/j.cplett.2021.138821
Yafei Liu, Wai Tuck Soh, Jun-Ichi Kishikawa, Mika Hirose, Emi E Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa, Sumiko Matsuoka, Kanako Akamatsu, Makoto Matsuda, Chikako Ono, Shiho Torii, Kazuki Kishida, Hui Jin, Wataru Nakai, Noriko Arase, Atsushi Nakagawa, Maki Matsumoto, Yukoh Nakazaki, Yasuhiro Shindo, Masako Kohyama, Keisuke Tomii, Koichiro Ohmura, Shiro Ohshima, Toru Okamoto, Masahiro Yamamoto, Hironori Nakagami, Yoshiharu Matsuura, Atsushi Nakagawa, Takayuki Kato, Masato Okada, Daron M Standley, Tatsuo Shioda, Hisashi Arase (2021)  An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies 184 :13,  3452-3466 DOI:10.1016/j.cell.2021.05.032 PMID:34139176 
Hirofumi Yamamoto, Naoki Sakai, Satoshi Ohte, Tomohiro Sato, Katsuhiko Sekimata, Takehisa Matsumoto, Kana Nakamura, Hisami Watanabe, Chiemi Mishima-Tsumagari, Akiko Tanaka, Yoshinobu Hashizume, Teruki Honma, Takenobu Katagiri, Kohei Miyazono, Hiroshi Tomoda, Mikako Shirouzu, Hiroo Koyama (2021)  Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva Bioorganic & Medicinal Chemistry Letters. 38 127858- DOI:10.1016/j.bmcl.2021.127858 PMID:33609658 
Hiroyuki Miyachi, Kayoko Kanamitsu, Mayumi Ishii, Eri, Watanabe, Akira Katsuyama, Satoko Otsuguro, Fumika Yakushiji, Mizuki Watanabe, Kouhei Matsui, Yukina Sato, Satoshi Shuto, Takashi Tadokoro, Shunsuke Kita, Takanori Matsumaru, Akira Matsuda, Tomoyasu Hirose, Masato Iwatsuki, Yasuteru Shigeta, Tetsuo Nagano, Hirotatsu Kojima, Satoshi Ichikawa, Toshiaki Sunazuka, Katsumi Maenaka (2021)  Structure, solubility, and permeability relationships in a diverse middle molecule library Bioorganic & Medicinal Chemistry Letters. 37 127847- DOI:10.1016/j.bmcl.2021.127847 PMID:33571648 
Ryota Kitakami , Kishin Inui , Yusuke Nakagawa , Yurika Sawai , Wakana Katayama , Takeshi Yokoyama , Takuya Okada , Kayoko Kanamitsu , Shinsaku Nakagawa , Naoki Toyooka , Mineyuki Mizuguchi  (2021)  Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis Bioorganic & Medicinal Chemistry Letters. 44 :15,  116292- DOI:10.1016/j.bmc.2021.116292 PMID:34225167 
Yui Kuroda , Miki Nonaka, Yuji Kamikubo , Haruo Ogawa , Takashi Murayama , Nagomi Kurebayashi , Hakushun Sakairi , Kanako Miyano , Akane Komatsu , Tetsushi Dodo , Kyoko Nakano-Ito , Keisuke Yamaguchi , Takashi Sakurai , Masako Iseki , Masakazu Hayashida , Yasuhito Uezono (2021)  Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors Biomed Pharmacother. 141 111800- DOI:10.1016/j.biopha.2021.111800 PMID:34175819 
Kentaro Inoue , Hiromitsu Araki , Fumihito Miura , Takashi Ito (2021)  Transcriptome dynamics during cholesterol-induced transdifferentiation of human coronary artery smooth muscle cells: A Gene Ontology-centric clustering approach Biochemistry Biophysics Reports. 27 101061- DOI:10.1016/j.bbrep.2021.101061 PMID:34258396 
Yusuke Sayama , Mika K Kaneko , Junko Takei , Hideki Hosono , Masato Sano , Teizo Asano , Yukinari Kato  (2021)  Establishment of a novel anti-TROP2 monoclonal antibody TrMab-29 for immunohistochemical analysis. Biochemistry and Biophysics Reports. 25 100902- DOI:10.1016/j.bbrep.2020.100902 PMID:33490649 
Keigo Tanaka, Naoki Dozono, Hiroyuki Neyama, Jun Nagai, Ryoko Tsukahara, Kazuki Nagayasu, Shuji Kaneko, Hiroshi Ueda (2021)  Secreted PLA2-III is a possible therapeutic target to treat neuropathic pain Biochemical and Biophysical Research Communications. 568 167-173 DOI:10.1016/j.bbrc.2021.06.058 PMID:34237486 
Koji Katsumata,Yuichi Ichikawa,Tomohiro Fuse,Hitoshi Kurumizaka,Akio Yanagida,Takeshi Urano,Hiroaki KatoMitsuhiro Shimizu (2021)  Sequence-dependent nucleosome formation in trinucleotide repeats evaluated by in vivo chemical mapping Biochemical and Biophysical Research Communications. 556 179-184 DOI:10.1016/j.bbrc.2021.03.155 PMID:33839413 
Satoshi Saijoh, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Ryo Ito, Akira Sugawara, Tomoko Yamazaki, Takayuki Imai, Yukinori Asada, Kazuto Matsuura, Wataru Iwai, Yuta Wakui, Makoto Abue, Sadafumi Kawamura, Yu Katayose, Haruna Fujimori, Mai Mochizuki, Jun Yasuda, Kazunori Yamaguchi, Kazuo Sugamura, Kennichi Satoh, Yukio Katori, Keiichi Tamai (2021)  Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein Biochemical and Biophysical Research Communications. 537 132-139 DOI:10.1016/j.bbrc.2020.11.022 PMID:33412384 
Keisuke Murakami, Satoru Nagatoishi, Keisuke Kasahara, Hirokazu Nagai, Yoshiyuki Sasajima, Ryo Sasaki, Kouhei Tsumoto (2021)  Electrostatic-triggered exothermic antibody adsorption to the cellulose nanoparticles Analytical Biochemistr. 632 114337- DOI:10.1016/j.ab.2021.114337 PMID:34391727 
Edurne Rujas, Daniel P. Leaman, Sara Insausti, Pablo Carravilla, Miguel Garcia-Porras, Eneko Largo, Izaskun Morillo, Ruben Sanchez-Eugenia, Lei Zhang, Hong Cui, Ibon Iloro, Felix Elortza, Jean-Philippe Julien, Christian Eggeling, Michael B. Zwick, Jose M.M. Caaveiro, Jose L. Nieva (2021)  Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile iScience. 24 :9,  102987- DOI:10.1016/ j.isci.2021.102987 PMID:34505005 
Naoki Sato, Takeshi Obayashi. (2021)  Lipid pathway databases with a focus on algae. Methods Mol Biol. 2295 455-468 DOI:10.1007/978-1-0716-1362-7_26 PMID:34047993 
Gert-Jan Bekker, Masashi Yokochi, Hirofumi Suzuki, Yasuyo Ikegawa, Takeshi Iwata, Takahiro Kudo, Kei Yura, Toshimichi Fujiwara, Takeshi Kawabata, Genji Kurisu (2021)  Protein Data Bank Japan: Celebrating our 20th anniversary during a global pandemic as the Asian hub of 3D macromolecular structural data Protein science. DOI:10.1002/pro.4211 PMID:34664328 
Masatomo So, Yuto Kimura, Keiichi Yamaguchi, Toshihiko Sugiki, Toshimichi Fujiwara, Cesar Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Yasushi Kawata, Yuji Goto (2021)  Polyphenol-solubility alters amyloid fibril formation of α-synuclein Protein Science. 30 :8,  1701-1713 DOI:10.1002/pro.4130 PMID:34046949 
Tadayoshi Kanao , Naruki Hase , Hisayuki Nakayama , Kyoya Yoshida , Kazumi Nishiura , Megumi Kosaka , Kazuo Kamimura , Yu Hirano 3 Taro Tamada  (2021)  Reaction mechanism of tetrathionate hydrolysis based on the crystal structure of tetrathionate hydrolase from Acidithiobacillus ferrooxidans Protein Science. 30 :2,  328-338 DOI:10.1002/pro.3984 PMID:33103311 
Hirohito Kubota, Tatsuya Masuda, Mina Noura, Kana Furuichi, Hidemasa Matsuo, Masahiro Hirata, Tatsuki R. Kataoka, Hidefumi Hiramatsu, Takahiro Yasumi, Tatsutoshi Nakahata, Yoichi Imai, Junko Takita, Souichi Adachi, Hiroshi Sugiyama, Yasuhiko Kamikubo (2021)  RUNX inhibitor suppresses graft-versus-host disease through targeting RUNX-NFATC2 axis British Journal of Haematology. DOI:10.1002/jha2.230
Otgontuya Ganbaatar , Satoru Konnai , Tomohiro Okagawa , Yutaro Nojima , Naoya Maekawa , Yoshiki Ichikawa , Atsushi Kobayashi , Tomoyuki Shibahara , Yojiro Yanagawa , Hidetoshi Higuchi , Yukinari Kato , Yasuhiko Suzuki , Shiro Murata , Kazuhiko Ohashi  (2021)  Programmed death-ligand 1 expression in swine chronic infections and enhancement of interleukin-2 production via programmed death-1/programmed death-ligand 1 blockade. Immun Inflamm Dis. DOI:10.1002/iid3.510 PMID:34414683 
Naoto Sugisawa, Hiroki Sugisawa, Yuma Otake, Roman V. Krems, Hiroyuki Nakamura, Shinichiro Fuse (2021)  Rapid and Mild One-Flow Synthetic Approach to Unsymmetrical Sulfamides Guided by Bayesian Optimization Chemistry Methods. DOI:10.1002/cmtd.202100053
Masahiro Kanaida, Aoi Kimishima, Shuhei Eguchi, Masato Iwatsuki, Yoshihiro Watanabe, Masako Honsho, Tomoyasu Hirose, Yoshihiko Noguchi, Kenichi Nonaka, Goh Sennari, Hidehito Matsui, Chikara Kaito, Hideaki Hanaki, Yukihiro Asami, Toshiaki Sunazuka  (2021)  Total Syntheses and Chemical Biology Studies of Hymeglusin and Fusarilactone A, Novel Circumventors of β-Lactam Drug Resistance in Methicillin-Resistant Staphylococcus aureus ChemMedChem. 16 :13,  2106-2111 DOI:10.1002/cmdc.202100219 PMID:33783142 
Daisuke Okuno, Noriho Sakamoto, Mohammed S O Tagod, Yoshiko Akiyama, Sakiko Moriyama, Takuto Miyamura, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Yuji Ishimatsu, Takashi Tanaka, Jun Ishihara, Kohsuke Takeda, Yoshimasa Tanaka, Hiroshi Mukae (2021)  Screening of inhibitors targeting heat shock protein 47 involved in the development of idiopathic pulmonary fibrosis. ChemMedChem. 16 :16,  2515-2523 DOI:10.1002/cmdc.202100064 PMID:33890415 
Hayama Tsutsumi,Yoshitaka Moriwaki,Tohru Terada,Kentaro Shimizu,Kazuo Shin-Ya,Yohei Katsuyama,Yasuo Ohnishi (2021)  Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C-6 Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C-6 Methyltransferase Angewandte Chemie - International Edition. DOI:10.1002/anie.202111217 PMID:34626048 
Yohei Katsuyama , Kaoru Sone , Ayaka Harada , Seiji Kawai , Naoki Urano , Naruhiko Adachi , Toshio Moriya , Masato Kawasaki , Kazuo Shin-Ya , Toshiya Senda , Yasuo Ohnishi  (2021)  Structural and functional analyses of the tridomain-nonribosomal peptide synthetase FmoA3 for 4-methyloxazoline ring formation. Angewandte Chemie - International Edition. 60 :26,  14554-14562 DOI:10.1002/anie.202102760 PMID:33783097 
Takeshi Yasui, Yuya Nakazato, Koutarou Kurisaki, and Yoshihiko Yamamoto (2021)  Enantioselective Construction of 5-6-5 Tricyclic Lactone Framework Bearing a Quaternary Bridgehead Carbon via Rh-Catalyzed Asymmetric [2+2+2] Cycloaddition of Enediynes Advanced Synthesis & Catalysis. 363 :17,  4182-4189 DOI:10.1002/adsc.202100513
Kyoko Furuita, Marina Hiraoka, Kentaro Hanada, Toshimichi Fujiwara, Chojiro Kojima (2021)  Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR FEBS Letters. 595 :17,  2248-2256 DOI:10.1002/1873-3468.14166 PMID:34312846 
Atsushi Hijikata , Clara Shionyu-Mitsuyama , Setsu Nakae , Masafumi Shionyu , Motonori Ota , Shigehiko Kanaya , Tsuyoshi Shirai (2021)  Knowledge‐based structural models of SARS‐CoV‐2 proteins and their complexes with potential drugs. FEBS Lett.. 594 :12,  1960-1973 DOI:10.1002/1873-3468.13806 PMID:32379896 

BINDSの支援を受けた研究成果(論文)

Hiroki Igarashi, Nobuaki Yasuo, Masakazu Sekijima (2021)  Leave-One-Element-Out Cross-Validation for Band Gap Prediction of Halide Double Perovskites Advances in Parallel & Distributed Processing, and Applications . 759-768 DOI:10.1007/978-3-030-69984-0_55
R. Kato, M. Hiraki, Y. Yamada, M. Tanabe and T. Senda (2021)  Improvement of Automated Crystallization and Monitoring System in PF PF Highlights 2020. 54-55
Hirotatsu Kojima (2021)  Supporting drug discovery research in Japan by Drug Discovery Initiative at the University of Tokyo Burger’s Medicinal Chemistry, Drug Discovery and Development 8th Ed., Wiley, Abraham, D.J., Myers M. ed.. 3 179-187 DOI:ISBN: 978-1-119-53030-5
Takatsugu Kosugi, Masahito Ohue (2021)  Quantitative estimate of protein-protein interaction targeting drug-likeness In Proceedings of The 18th IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB 2021). DOI:10.26434/chemrxiv.14489769.v1
Masahito Ohue, Yutaka Akiyama (2021)  MEGADOCK-GUI: a GUI-based complete cross-docking tool for exploring protein-protein interactions In Proceedings of The 27th International Conference on Parallel & Distributed Processing Techniques and Applications (PDPTA’21). DOI:https://arxiv.org/pdf/2105.03617.pdf
Yoshiaki Kawano, Masahide Hikita, Naohiro Matsugaki, Masaki Yamamoto and Toshiya Senda (2021)  Crystal processing machine using a deep-ultraviolet laser-application to long-wavelength native SAD experiments Acta Crystallographica Section F: Structural Biology Communications.
Mayuka Higo, Hiroki Kojima, Masato Iwatsuki, Tomotaka Tanabe, Takashi Yaguchi, Toru Okuda, Taiga Kasuya, Kenichi Nonaka (2021)  Lecanicillium aphanocladii isolated from Tengu-no-Mugimeshi found in Mount Kurohime, Nagano Prefecture, central Japan Microbial Resources and Systematics. 37 DOI:ISSN:1342-4041
Ko Sato Ko Sato, Amarjeet Kumar, Keisuke Hamada, Chikako Okada, Asako Ogun, Ayumi Machiyama, Shun Sakuraba, Tomohiro Nishizawa, Osamu Nureki, Hidetoshi Kono, Kazuhiro Ogata, Toru Sengoku ,  (2021)  Structural mechanism regulating normal and oncogenic methylation of nucleosomal histone H3K36 by NSD2 DOI:10.1101/2020.12.05.413278 PMID:bioRxiv 
Kenta Hayami, Yuichi Kuboki, Katsumi Ohta, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Jun-Ichi Haruta , Kenichi Murai, Hiromichi Fujioka, Akira Asai, Mitsuhiro Arisawa (2021)  Design, Synthesis, Physical Properties and Indoleamine 2, 3-Dioxygenase 1 Inhibitory Activity of Substitued Indole Derivatives with N-H, N-Metohymethyl, or N-Mehylthiomethyl Group toward Fragment-Based Drug Discovery Heterocycles. 103 :1,  511-525 DOI:10.3987/COM-20-S(K)35
Kei Moritsugu (2021)  Multiscale Enhanced Sampling Using Machine Learning Life. 11 :10,  1076- DOI:10.3390/life11101076 PMID:34685447  
Toshihiko Matsuo , Shihui Liu , Tetsuya Uchida , Satomi Onoue , Shinsaku Nakagawa , Mayumi Ishii and Kayoko Kanamitsu  (2021)  Photoelectric Dye, NK-5962, as a Potential Drug for Preventing Retinal Neurons from Apoptosis: Pharmacokinetic Studies Based on Review of the Evidence Life . 11 :6,  591- DOI:10.3390/life11060591 PMID:34205684 
Takuya Kobayashi, Nagomi Kurebayashi, Takashi Murayama (2021)  The ryanodine receptor as a sensor for intracellular environments in muscles. International Journal of Molecular Sciences. 22 :19,  10795- DOI:10.3390/ijms221910795 PMID:34639137 
Kento Fujiwara, Masaki Kitaura, Ayaka Tsunei, Hotaka Kusabuka, Erika Ogaki, Naoki Okada (2021)  Structure of the Signal Transduction Domain in Second-Generation CAR Regulates the Input Efficiency of CAR Signals International Journal of Molecular Sciences . 22 :5,  2476- DOI:10.3390/ijms22052476 PMID:33804441 
Yasuka Matsunaga, Shun Hasei, Takeshi Yamamotoya, Hiroaki Honda, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Yusuke Nakatsu (2021)  Pathological Role of Pin1 in the Development of DSS-Induced Colitis. Cells. 10 :5,  1230- DOI:10.3390/cells10051230 PMID:34067858 
Koji Kitamura, Keisuke Nimura (2021)  Regulation of RNA splicing: Aberrant splicing regulation and therapeutic targets in cancer Cells. 10 :4,  923- DOI:10.3390/cells10040923 PMID:33923658 
Natsuki Osaka, Yoshihisa Hirota, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Venkat R Chirasani, Sharon L Campbell, Koh Takeuchi, Toshiya Senda, Atsuo T Sasaki (2021)  Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification Frontiers in Molecular Biosciences. 8 707439- DOI:10.3389/fmolb.2021.707439 PMID:34307463 
Takashi Niwa, Yuta Uetake, Motoyuki Isoda, Tadashi Takimoto, Miki Nakaoka, Daisuke Hashizume, Hidehiro Sakurai, Takamitsu Hosoya (2021)  Lewis acid-mediated Suzuki-Miyaura cross-coupling reaction chemRxiv. DOI:10.33774/chemrxiv-2021-kmfr5-v3
Yifan Hu, Kavita A Iyer, Ashok R Nayak, Nagomi Kurebayashi, Takashi Murayama, Montserrat Sams (2021)  Purification of recombinant wild type and mutant ryanodine receptors expressed in HEK293 cells Bio-protocol . 11 :15,  e4112- DOI:10.21769/BioProtoc.4112 PMID:34458406 
Taishi Onodera, Shunsuke Kita, Yu Adachi, Saya Moriayma, Akihiko Sato, Takao Nomura, Takeshi Inoue, Takashi Tadokoro, Yuki Anraku, Kohei Yumoto, Cong Tian, Hideo Fukuhara, Michihito Sasaki, Yasuko Orba, Nozomi Shiwa, Naoko Iwata, Noriyo Nagata, Tateki Suzuki, Jiei Sasaki, Tsuyoshi Sekizuka, Keisuke Tonouchi, Shuetsu Fukushi, Hiroyuki Satofuka, Yasuhiro Kazuki, Lin Sun, Mitsuo Oshimura, Tomohiro Kurosaki, Makoto Kuroda, Tadaki Suzuki, Hirofumi Sawa, Takao Hashiguchi, Katsumi Maenaka, Yoshimasa Takahashi,  (2021)  Broad Neutralization Activity of SARS-CoV-2 Antibody is Achieved by Coordinated Recognition of Virus Vulnerable Site Sneak Peek. DOI:10.2139/ssrn.3817803
Haon Futamata, Masahiro Fukuda, Rie Umeda, Keitaro Yamashita, Satoe Takahashi, Takafumi Shikakura, Shigehiko Hayashi, Kazuaki Homma, Tomohiro Nishizawa, Osamu Nureki (2021)  Cryo-EM structures reveal the electromotility mechanism of prestin, the cochlear amplifier nature portfolio. DOI:10.21203/rs.3.rs-927386/v1
Makiko Kosugi, Masato Kawasaki, Yutaka Shibata, Kojiro Hara, Shinichi Takaichi, Toshio Moriya, Naruhiko Adachi, Yasuhiro Kamei, Yasuhiro Kashino, Sakae Kudoh, Hiroyuki Koike, Toshiya Senda (2021)  Uphill energy transfer mechanism for photosynthesis in the Antarctic alga research square. DOI:10.21203/rs.3.rs-701485/v1
Satoshi Abe,Kazuhisa Honma, Akane Okada,Kanako Kazuki,Hiroshi Tanaka, Takeshi Endo, Kayoko Morimoto, Takashi Moriwaki,ShuseiHamamichi,YujiNakayama,TeruhikoSuzuki,ShokoTakehara,MitsuoOshimura,Yasuhiro Kazuki (2021)  Construction of Stable Mouse Artificial Chromosome from Native Mouse Chromosome 10 for Generation of Transchromosomic Mice Scientific Reports. 11 :1,  20050- DOI:10.21203/rs.3.rs-675300/v1
Ryoya Nakagawa, Soh Ishiguro, Sae Okazaki, Hideto Mori, Mamoru Tanaka, Hiroyuki Aburatani, Nozomu Yachie, Hiroshi Nishimasu, Osamu Nureki (2021)  Engineered Campylobacter jejuni Cas9 variant with enhanced activity nature portfolio. DOI:10.21203/rs.3.rs-512474/v1
Yuxia Zhang , Satoshi Watanabe , Akihisa Tsutsumi , Hiroshi Kadokura , Masahide Kikkawa , Kenji Inaba  (2021)  Cryo-EM analysis provides new mechanistic insight into ATP binding to Ca 2+ -ATPase SERCA2b EMBO J. 40 :19,  e108482- DOI:10.15252/embj.2021108482 PMID:34459010 
Takeshi Nara, Yukari Nakagawa, Keiko Tsuganezawa, Hitomi Yuki, Katsuhiko Sekimata, Hiroo Koyama, Naoko Ogawa, Teruki Honma, Mikako Shirouzu, Takehiro Fukami, Yuichi Matsuo, Daniel Ken Inaoka, Kiyoshi Kita, Akiko Tanaka (2021)  The ubiquinone synthesis pathway is a promising drug target for Chagas disease. PLoS One. 16 :2,  e0243855- DOI:10.1371/journal.pone.0243855 PMID:33539347 
Jesse I Mobbs, Matthew J Belousoff, Kaleeckal G Harikumar, Sarah J Piper, Xiaomeng Xu, Sebastian G B Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M Thal, Laurence J Miller, Patrick M Sexton (2021)  Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity PLoS Biology. 19 :6,  e3001295- DOI:10.1371/journal.pbio.3001295 PMID:34086670 
Fei Jin, Minxuan Sun, Takashi Fujii, Yurika Yamada, Jin Wang, Andres D Maturana, Miki Wada, Shichen Su, Jinbiao Ma, Hironori Takeda, Tsukasa Kusakizako, Atsuhiro Tomita, Yoshiko Nakada-Nakura, Kehong Liu, Tomoko Uemura, Yayoi Nomura, Norimichi Nomura, Koichi Ito, Osamu Nureki, Keiichi Namba, So Iwata, Ye Yu, Motoyuki Hattori (2021)  The structure of MgtE in the absence ofmagnesium provides new insights intochannel gating PLoS Biology. 19 :4,  e3001231- DOI:10.1371/journal.pbio.3001231 PMID:33905418 
Satoshi Matsuyama , Munmun Pervin , Minto Nakagawa , Takeshi Izawa , Mitsuru Kuwamura , Jyoji Yamate (2021)  Properties of macrophages and lymphocytes appearing in rat renal fibrosis followed by repeated injection of cisplatin The Journal of Veterinary Medical Science. DOI:10.1292/jvms.21-0341 PMID:34305076 
Tomonori Kameda, Hideyuki Nakashima, Takumi Takizawa, Fumihito Miura, Takashi Ito, Kinichi Nakashima, Takuya Imamura (2021)  Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation Journal of Reproduction and Development. DOI:10.1262/jrd.2021-106 PMID:34615840 
Ryo Saito, Goh Sennari, Asuka Nakajima, Aoi Kimishima, Masato Iwatsuki, Aki Ishiyama, Rei Hokari, Tomoyasu Hirose, Toshiaki Sunazuka (2021)  Discoveries and Syntheses of Highly Potent Antimalarial Troponoids Chemical and Pharmaceutical Bulletin. 69 :6,  564-572 DOI:10.1248/cpb.c21-00132 PMID:34078803 
Yukiko Karuo, Riona Shiraki, Ayaka Yoshida, Ryo Tsunokawa, Mayuko Nakahara-Yamada, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote, Hitoshi Nishimura (2021)  Identification and Synthesis of DDI-6, a Quinolinol Analog Capable of Activating Both Caenorhabditis elegans and Mouse Spermatozoa Chemical and Pharmaceutical Bulletin. 69 :6,  557-563 DOI:10.1248/cpb.c21-00127 PMID:34078802 
Yusuke Sasano, Aoto Yamaichi, Ryota Sasaki, Shota Nagasawa, Yoshiharu Iwabuchi (2021)  Expansion of Substrate Scope for Nitroxyl Radical/Copper-Catalyzed Aerobic Oxidation of Primary Alcohols: A Guideline for Catalyst Selection Chemical & pharmaceutical bulletin. 69 :5,  488-497 DOI:10.1248/cpb.c21-00043 PMID:33952858 
Chisato Okajima, Naoki Imakawa, Kazuya Nagano, Masayoshi Arai, Mitsuhiro Arisawa, Misa Muraoka, Hirofumi Tsujino, Yoshihiko Hirata, Kazumasa Hirata (2021)  Inhibitory Activity and Proposed Binding Model of γ-Glutamyl Cysteine, the Precursor of Glutathione, on Angiotensin Converting Enzyme BPB Reports. 4 :4,  116-119 DOI:10.1248/bpbreports.4.4_116
Yosuke Hashimoto, Matthew Campbell, Keisuke Tachibana, Yoshiaki Okada, Masuo Kondoh (2021)  Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier Biological & pharmaceutical bulletin. 44 :10,  1380-1390 DOI:10.1248/bpb.b21-00408 PMID:34602546 
Shigehiro Ohdo (2021)  Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level Biological & pharmaceutical bulletin. 44 :6,  747-761 DOI:10.1248/bpb.b21-00277 PMID:34078807 
Daichi Egawa, Taku Ogiso, Kimina Nishikata, Keiko Yamamoto, Toshimasa Itoh (2021)  Structural Insights into the Loss-of-Function R288H Mutant of Human PPARγ Biological and Pharmaceutical Bulletin. 44 :9,  1196-1201 DOI:10.1248/bpb.b21-00253 PMID:34471047 
Akihiro Honda , Shotaro Kamata, Chihiro Satta , Yui Machida , Kie Uchii , Kazuki Terasawa , Ayane Nemoto, Takuji Oyama , Isao Ishii (2021)  Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist Biological and Pharmaceutical Bulletin. 44 :9,  1210-1219 DOI:10.1248/bpb.b21-00232 PMID:34471049 
Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata, and Masamitsu Honma (2021)  Development of a new quantitative structure-activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDropTM Auto-ModellerTM Genes and Environment. 43 :1,  16- DOI:10.1186/s41021-021-00182-6 PMID:33931133 
Phuong Thuy Viet Nguyen, Truong Van Dat, Shusaku Mizukami, Duy Le Hoang Nguyen, Farhana Mosaddeque, Son Ngoc Kim, Duy Hoang Bao Nguyen, Oanh Thi Dinh, Tu Linh Vo, Giang Le Tra Nguyen, Cuong Quoc Duong, Satoshi Mizuta, Dao Ngoc Hien Tam, M. Phuong Truong, Nguyen Tien Huy and Kenji Hirayama (2021)  2D-quantitative structure-activity relationships model using PLS method for anti-malarial activities of anti-haemozoin compounds Malar Journal. 20 :1,  264- DOI:10.1186/s12936-021-03775-2 PMID:34116665 
Amrita Srivathsan, Leshon Lee, Kazutaka Katoh, Emily Hartop, Sujatha Narayanan Kutty, Johnathan Wong, Darren Yeo and Rudolf Meier (2021)  ONTbarcoder and MinION-based barcoding aid in democratizing biodiversity discovery BMC Biology. 19 :1,  217- DOI:10.1186/s12915-021-01141-x PMID:34587965 
Yoshihisa Hirakawa, Miki Senda, Kodai Fukuda, Hong Yang Yu, Masaki Ishida, Masafumi Taira, Kazushi Kinbara, Toshiya Senda (2021)  Characterization of a novel type of carbonic anhydrase that acts without metal cofactors BMC Biology. 19 :1,  105- DOI:10.1186/s12915-021-01039-8 PMID:34006275 
Shuhei Kanagaki, Takahiro Suezawa, Keita Moriguchi, Kazuhisa Nakao, Masayasu Toyomoto, Yuki Yamamoto, Koji Murakami, Masatoshi Hagiwara, Shimpei Gotoh (2021)  Hydroxypropyl Cyclodextrin Improves Amiodarone-Induced Aberrant Lipid Homeostasis of Alveolar Cells American Journal of Respiratory Cell and Molecular Biology. 64 :4,  504-514 DOI:10.1165/rcmb.2020-0119OC PMID:33493427 
Takuma Toyonaga, Takayuki Kato, Akihiro Kawamoto, Noriyuki Kodera, Tasuku Hamaguchi, Yuhei O Tahara, Toshio Ando, Keiichi Namba, Makoto Miyata (2021)  Chained structure of dimeric F1-like ATPase in Mycoplasma mobile gliding machinery. mBio. 12 :4,  e0141421- DOI:10.1128/MBIO.01414-21 PMID:34281395 
Shogo Nakajima, Koichi Watashi, Takanobu Kato, Masamichi Muramatsu, Takaji Wakita, Noriko Tamura, Shin-Ichiro Hattori, Kenji Maeda, Hiroaki Mitsuya, Yoshiaki Yasutake, Tetsuya Toyoda (2021)  Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations Journal of Virology. 95 :16,  e02401-20- DOI:10.1128/JVI.02401-20 PMID:34076480 
Dmitry Ghilarov, Satomi Inaba-Inoue, Piotr Stepien, Feng Qu, Elizabeth Michalczyk, Zuzanna Pakosz, Norimichi Nomura, Satoshi Ogasawara, Graham Charles Walker, Sylvie Rebuffat, So Iwata, Jonathan Gardiner Heddle, Konstantinos Beis (2021)  Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides Science Advances. 7 :37,  eabj5363- DOI:10.1126/sciadv.abj5363 PMID:34516884 
Mutsuko Kukimoto-Niino , Kazushige Katsura , Rahul Kaushik , Haruhiko Ehara , Takeshi Yokoyama , Tomomi Uchikubo-Kamo , Reiko Nakagawa , Chiemi Mishima-Tsumagari , Mayumi Yonemochi , Mariko Ikeda , Kazuharu Hanada , Kam Y J Zhang , Mikako Shirouzu (2021)  Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex Science Advances. 7 :30,  eabg3147- DOI:10.1126/sciadv.abg3147 PMID:34290093 
Laura Bracun, Atsushi Yamagata, Bern M Christianson, Tohru Terada, Daniel P Canniffe, Mikako Shirouzu, Lu-Ning Liu (2021)  Cryo-EM structure of the photosynthetic RC-LH1-PufX supercomplex at 2.8-A resolution Science Advances. 7 :25,  eabf8864- DOI:10.1126/sciadv.abf8864 PMID:34134992 
Shintaro Maeda , Yuki Shiimura , Hidetsugu Asada , Kunio Hirata , Fangjia Luo , Eriko Nango , Nobuo Tanaka , Masayasu Toyomoto , Asuka Inoue , Junken Aoki , So Iwata , Masatoshi Hagiwara  (2021)  Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias Science Advances. 7 :24,  eabf5325- DOI:10.1126/sciadv.abf5325 PMID:34108205 
Stephanie Schumacher, Dirk Dedden, Roberto Vazquez Nunez, Kyoko Matoba, Junichi Takagi, Christian Biertumpfel, Naoko Mizuno (2021)  Structural insights into the integrin α5β1 opening by fibronectin ligand. Science Advances. 7 :19,  eabe9716- DOI:10.1126/sciadv.abe9716 PMID:33962943 
Kiyoshi Yoshioka, Hiroshi Nagahisa, Fumihito Miura, Hiromitsu Araki, Yasutomi Kamei, Yasuo Kitajima, Daiki Seko, Jumpei Nogami, Yoshifumi Tsuchiya, Narihiro Okazaki, Akihiko Yonekura, Seigo Ohba, Yoshinori Sumita, Ko Chiba, Kosei Ito, Izumi Asahina, Yoshihiro Ogawa, Takashi Ito, Yasuyuki Ohkawa, Yusuke Ono (2021)  Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle Science Advances. 7 :24,  eabd7924- DOI:10.1126/sciadv.abd7924 PMID:34108202 
Aya Shiba-Ishii (2021)  Significance of stratifin in early progression of lung adenocarcinoma and its potential therapeutic relevance International Journal of Surgical Pathology. 71 :10,  655-665 DOI:10.1111/pin.13147 PMID:34324245 
Koji Sakata, Sho Matsuyama, Nagomi Kurebayashi, Kengo Hayamizu, Takashi Murayama, Kunihide Nakamura, Kazuo Kitamura, Sachio Morimoto, Ryu Takeya (2021)  Differential effects of the formin inhibitor SMIFH2 on contractility and Ca2+ handling in frog and mouse cardiomyocytes Genes to Cells. 26 :8,  583-595 DOI:10.1111/gtc.12873 PMID:34060165 
Takashi Imada, Takeshi Shimi, Ai Kaiho, Yasushi Saeki, Hiroshi Kimura  (2021)  RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells Gens to cells. 26 :5,  298-312 DOI:10.1111/gtc.12840 PMID:33608942 
Takashi Fujishiro, Miho Ooi, Kyosei Takaoka (2021)  Crystal structure of Escherichia coli class II hybrid cluster protein, HCP, reveals a [4Fe-4S] cluster at the N-terminal protrusion The FEBS Journal. DOI:10.1111/febs.16062 PMID:34101368 
Evdokia-Anastasia Giannopoulou, Miki Senda, Maharani Pertiwi Koentjoro, Naruhiko Adachi, Naoto Ogawa, Toshiya Senda (2021)  Crystal structure of the full-length LysR-type transcription regulator CbnR in complex with promoter DNA The FEBS Journal. 288 :15,  4560-4575 DOI:10.1111/febs.15764 PMID:33576566 
Isabel Sebastian, Nobuhiko Okura, Bruno M Humbel, Jun Xu, Idam Hermawan, Chiaki Matsuura, Malgorzata Hall, Chitoshi Takayama, Tetsu Yamashiro, Shuichi Nakamura, Claudia Toma (2021)  Disassembly of the apical junctional complex during the transmigration of Leptospira interrogans across polarized renal proximal tubule epithelial cells cellular microbiology. 23 :9,  e13343.- DOI:10.1111/cmi.13343 PMID:33864347 
Mina Noura , Ken Morita , Hiroki Kiyose , Yukiko Okuno , Hidemasa Matsuo, Asami Koyama , Yoko Nishinaka-Arai , Yasuhiko Kamikubo , Souichi Adachi  (2021)  Albendazole induces the terminal differentiation of acute myeloid leukaemia cells to monocytes by stimulating the Kruppel-like factor 4-dihydropyrimidinase-like 2A (KLF4-DPYSL2A) axis British Journal of Haematology. 194 :3,  598-603 DOI:10.1111/bjh.17557 PMID:34227104 
Andrea Cellini, Weixiao Yuan Wahlgren, Leocadie Henry, Suraj Pandey, Swagatha Ghosh, Leticia Castillon, Elin Claesson, Heikki Takala, Joachim Kubel, Amke Nimmrich, Valentyna Kuznetsova, Eriko Nango, So Iwata, Shigeki Owada, Emina A Stojkovic, Marius Schmidt, Janne A Ihalainen, Sebastian Westenhoff (2021)  The three-dimensional structure of Drosophila melanogaster (6-4) photolyase at room temperature Acta Crystallographica Section D: Structural Biology. 77 1001-1009 DOI:10.1107/S2059798321005830 PMID:34342273 
Risako Tamura-Sakaguchi, Rie Aruga, Mika Hirose, Toru Ekimoto, Takuya Miyake, Yohei Hizukuri, Rika Oi, Mika K Kaneko, Yukinari Kato, Yoshinori Akiyama, Mitsunori Ikeguchi, Kenji Iwasaki, Terukazu Nogi (2021)  Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope-tag insertion Acta Crystallographica Section D: Structural Biology. 77 645-662 DOI:10.1107/S2059798321002527 PMID:33950020 
Takeshi Murakawa, Mamoru Suzuki, Toshi Arima, Michihiro Sugahara, Tomoyuki Tanaka, Rie Tanaka, So Iwata, Eriko Nango, Kensuke Tono, Hideyuki Hayashi, Kenji Fukui, Takato Yano, Katsuyuki Tanizawa, Toshihide Okajima (2021)  Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase Acta Crystallographica Section F: Structural Biology Communications .. 77 356-363 DOI:10.1107/S2053230X21008967 PMID:34605440 
Akinori Kidera, Kei Moritsugu, Toru Ekimoto, Mitsunori Ikeguchi (2021)  Allosteric regulation of 3CL protease of SARS-CoV-2 and SARS-CoV observed in the crystal structure ensemble bioRxiv. DOI:10.1101/2021.08.29.458083
Koya Sakuma, Naohiro Kobayashi, Toshihiko Sugiki, Toshio Nagashima, Toshimichi Fujiwara, Kano Suzuki, Naoya Kobayashi, Takeshi Murata, Takahiro Kosugi, Rie Koga, Nobuyasu Koga (2021)  Design of complicated all-α protein structures bioRxiv. DOI:10.1101/2021.07.14.449347
Kaoru Fujimoto, Akinobu Senoo, Satoru Nagatoishi, Daisuke Takahashi, Tadashi Ueda, Kouhei Tsumoto, Jose M.M. Caaveiro (2021)  Lipid nanodiscs facilitate the identification of a fragment compound inhibiting the enzymatic activity of the bacterial membrane protein MsbA BioRxiv. DOI:10.1101/2021.06.15.448612
Keijun Kakihara, Kengo Asamizu, Kei Moritsugu, Masahide Kubo, Tetsuya Kitaguchi, Akinori Endo, Akinori Kidera, Mitsunori Ikeguchi, Akira Kato, Masayuki Komada, Toshiaki Fukushima (2021)  The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain bioRxiv. DOI:10.1101/2021.05.31.446389
Shohei Nosaki, Mika K Kaneko, Fuminori Tsuruta, Hideki Yoshida, Yukinari Kato, Kenji Miura (2021)  Prevention of necrosis caused by transient expression in Nicotiana benthamiana by application of ascorbic acid Plant Physiol. 186 :2,  832-835 DOI:10.1093/plphys/kiab102 PMID:33638348 
Keisuke Oki, Mariko Nagata, Takeshi Yamagami, Tomoyuki Numata, Sonoko Ishino, Takuji Oyama, Yoshizumi Ishino (2021)  Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome Nucleic Acids Research. DOI:10.1093/nar/gkab799 PMID:34568951 
Masahiko Okuda, Tetsufumi Suwa, Hidefumi Suzuki, Yuki Yamaguchi, Yoshifumi Nishimura (2021)  Three human RNA polymerases interact with TFIIH via a common RPB6 subunit Nucleic Acids Research. DOI:10.1093/nar/gkab612 PMID:34268577 
Satoru Ishihara, Yohei Sasagawa, Takeru Kameda, Hayato Yamashita, Mana Umeda, Naoe Kotomura, Masayuki Abe, Yohei Shimono, Itoshi Nikaido (2021)  Local states of chromatin compaction at transcription start sites control transcription levels Nucleic Acids Research. 49 :14,  8007-8023 DOI:10.1093/nar/gkab587 PMID:34233004 
Yuichiro Mita, Risa Uchida, Sayuri Yasuhara, Kohei Kishi, Takayuki Hoshi, Yoshitaka Matsuo, Tadashi Yokooji, Yoshino Shirakawa, Takashi Toyama, Yasuomi Urano, Toshifumi Inada, Noriko Noguchi, Yoshiro Saito (2021)  Identification of a Novel Endogenous Long Non-coding RNA that Inhibits Selenoprotein P Translation. Nucleic Acids Research. 49 :12,  6893-6907 DOI:10.1093/nar/gkab498 PMID:34142161 
Masahiko Okuda, Toru Ekimoto, Jun-ichi Kurita, Mitsunori Ikeguchi, Yoshifumi Nishimura (2021)  Structural and dynamical insights into the PH domain of p62 in human TFIIH. Nucleic Acids Research. 49 :5,  2916-2930 DOI:10.1093/nar/gkaa1045 PMID:33211877 
Radostin Danev, Haruaki Yanagisawa, Masahide Kikkawa (2021)  Cryo-EM performance testing of hardware and data acquisition strategies microscopy(oxf). DOI:10.1093/jmicro/dfab016 PMID:33969878 
Katsuyuki Sakai, Yufu Unten, Aoi Kimishima, Kenichi Nonaka, Takumi Chinen, Kazunari Sakai, Takeo Usui, Kazuro Shiomi, Masato Iwatsuki, Masatoshi Murai, Hideto Miyoshi, Yukihiro Asami, Satoshi ?mura (2021)  Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria Journal of Industrial Microbiology and Biotechnology. 74 :6,  DOI:10.1093/jimb/kuab051 PMID:34343309 
Sayako Hirose, Takashi Murayama, Naoyuki Tetsuo, Minako Hoshiai, Hiroaki Kise, Masao Yoshinaga, Hisaaki Aoki, Megumi Fukuyama, Yimin Wuriyanghai, Yuko Wada, Koichi Kato, Takeru Makiyama,, Takeshi Kimura, Takashi Sakurai, Minoru Horie, Nagomi Kurebayashi, Seiko Ohno (2021)  Loss-of-Function Mutations in Cardiac Ryanodine Receptor Channel Cause Various Types of Arrhythmias Including Long QT Syndrome EP Europace. DOI:10.1093/europace/euab250 PMID: 34661651 
Tomonari Muramatsu and Masaru Tanokura (2021)  A novel method of literature mining to identify candidate COVID-19 drugs Bioinformatics Advances. 1 :1,  vbab013- DOI:10.1093/bioadv/vbab013
Nami Tateyama, Ren Nanamiya, Tomokazu Ohishi, Junko Takei, Takuro Nakamura, Miyuki Yanaka, Hideki Hosono, Masaki Saito, Teizo Asano, Tomohiro Tanaka, Masato Sano, Manabu Kawada, Mika K Kaneko, Yukinari Kato (2021)  Defucosylated Anti-Epidermal Growth Factor Receptor Monoclonal Antibody 134-mG2a-f Exerts Antitumor Activities in Mouse Xenograft Models of Dog Epidermal Growth Factor Receptor-Overexpressed Cells Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :4,  177-183 DOI:10.1089/mab.2021.0022 PMID:34424762 
Tomohiro Tanaka , Teizo Asano , Masato Sano , Junko Takei , Hideki Hosono , Ren Nanamiya , Nami Tateyama , Mika K Kaneko , Yukinari Kato (2021)  Epitope Mapping of the Anti-California Sea Lion Podoplanin Monoclonal Antibody PMab-269 Using Alanine-Scanning Mutagenesis and ELISA Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40 :4,  196-200 DOI:10.1089/mab.2021.0017 PMID:34283661 
Teizo Asano, Ren Nanamiya, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato (2021)  Development of Antihuman Killer Cell Lectin-Like Receptor Subfamily G Member 1 Monoclonal Antibodies for Flow Cytometry Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 40 :2,  76-80 DOI:10.1089/mab.2021.0008 PMID:33900816 
Hana Inoue, Takashi Murayama, Takuya Kobayashi, Masato Konishi, Utako Yokoyama (2021)  The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity Journal of General Physiology. 153 :6,  e202012708- DOI:10.1085/jgp.202012708 PMID:3399118 
Taito Kashio, Keisuke Shirakura, Mayumi Kinoshita, Maaya Morita, Ryosuke Ishiba, Kosuke Muraoka, Tomoaki Kanbara, Masato Tanaka, Risa Funatsu, Nobumasa Hino, Shohei Koyama, Ryo Suzuki, Yasuo Yoshioka, Taiki Aoshi, Takefumi Doi, Yoshiaki Okada (2021)  HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells Tissue Barriers. 9 :3,  1911195- DOI:10.1080/21688370.2021.1911195 PMID:33955828 
Junki Hirano, Sachiyo Yoshio, Yusuke Sakai, Li Songling, Tatsuya Suzuki, Yumi Itoh, He Zhang, David Virya Chen, Saori Haga, Hiroko Oomori, Takahiro Kodama, Yusuke Maeda, Yoshihiro Ono, Yu Takahashi, Daron M Standley, Masahiro Yamamoto, Kohji Moriishi, Kyoji Moriya, Tatsuya Kanto, Tetsuo Takehara, Kazuhiko Koike, Yoshiharu Matsuura, Toru Okamoto (2021)  Hepatitis C virus modulates signal peptide peptidase to alter host protein processing Proceedings of the National Academy of Sciences . 118 :22,  e2026184118- DOI:10.1073/pnas.2026184118 PMID:34035171 
Takayuki Nagae, Masashi Unno, Taiki Koizumi, Yohei Miyanoiri, Tomotsumi Fujisawa, Kento Masui, Takanari Kamo, Kei Wada, Toshihiko Eki, Yutaka Ito, Yuu Hirose, Masaki Mishima (2021)  Structural basis of the protochromic green/red photocycle of the chromatic acclimation sensor RcaE Proceedings of the National Academy of Sciences . 118 :20,  e2024583118- DOI:10.1073/pnas.2024583118 PMID:33972439 
Ryuta Kanai, Flemming Cornelius,eHaruo Ogawa, Kanna Motoyama, Bente Vilsen,eChikashi Toyoshima (2021)  Binding of cardiotonic steroids to Na+,K+-ATPase in the E2P state Proceedings of National Academy of Science USA.. 118 :4,  e2020438118- DOI:10.1073/pnas.2020438118 PMID:33318128 
Ohno, Shohei, Miyoshi, Makoto, Murai, Kenichi, Arisawa, Mitsuhiro (2021)  Non-directed ?- or ?-C(sp3)-H Functionalization of Saturated Nitrogen-containing. Heterocycles. Synthesis. 53 :17,  2947-2960 DOI:10.1055/a-1483-4575
Kohei Suzuki, Kota Katayama Yuji Sumii,Tomoya Nakagita, Ryoji Suno, Hirokazu Tsujimoto, So Iwata, Takuya Kobayashi, Norio Shibata and Hideki Kandori (2021)  Vibrational analysis of acetylcholine binding to the M2 receptor Royal Society of Chemistry. 11 :21,  12559-12567 DOI:10.1039/d1ra01030a
Takahiro Aimi, Tomohiro Meguro, Akihiro Kobayashi, Takamitsu Hosoya, and Suguru Yoshida (2021)  Nucleophilic transformations of azido-containing carbonyl compounds via protection of azido group Chemical communications. 57 :49,  6062-6065 DOI:10.1039/D1CC01143J PMID:34036976 
Chiduru Watanabe, Yoshio Okiyama, Shigenori Tanaka, Kaori Fukuzawa and Teruki Honma  (2021)  Molecular Recognition of SARS-CoV-2 Spike Glycoprotein: Quantum Chemical Hot Spot and Epitope Analyses. Chemical Science. 12 :13,  4722-4739 DOI:10.1039/D0SC06528E
Mari Hashimoto, Yoriko Saito, Ryo Nakagawa, Ikuko Ogahara, Shinsuke Takagi, Sadaaki Takata, Hanae Amitani, Mikiko Endo, Hitomi Yuki, Jordan A. Ramilowski, Jessica Severin, Ri-ichiroh Manabe, Takashi Watanabe, Kokoro Ozaki, Akiko Kaneko, Hiroshi Kajita, Saera Fujiki, Kaori Sato, Teruki Honma, Naoyuki Uchida, Takehiro Fukami, Yasushi Okazaki, Osamu Ohara, Leonard D. Shultz, Makoto Yamada, Shuichi Taniguchi, Paresh Vyas, Michiel de Hoon, Yukihide Momozawa & Fumihiko Ishikawa (2021)  Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia. Nature Cancer. 2 :3,  340-356 DOI:10.1038/s43018-021-00177-w
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E Bianchi, Hitoshi Okazawa (2021)  HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology Communications Biology. 4 :1,  1175- DOI:10.1038/s42003-021-02671-4 PMID:34635772 
Kazutaka Katoh, Daron M Standley (2021)  Emerging SARS-CoV-2 variants follow a historical pattern recorded in outgroups infecting non-human hosts. Communications Biology. 4 :1,  1134- DOI:10.1038/s42003-021-02663-4 PMID:34552191 
Mirai Tanigawa, Katsuyoshi Yamamoto, Satoru Nagatoishi, Koji Nagata, Daisuke Noshiro, Nobuo N Noda, Kouhei Tsumoto, Tatsuya Maeda (2021)  A glutamine sensor that directly activates TORC1 Nature Communications. 4 :1,  1093- DOI:10.1038/s42003-021-02625-w PMID:34535752 
Yuya Taguchi, Takahiro Yamasaki, Marie Ishikawa, Yuki Kawasaki, Ryuji Yukimura, Maki Mitani, Kunio Hirata, Daisuke Kohda (2021)  The structure of an archaeal oligosaccharyltransferase provides insight into the strict exclusion of proline from the N-glycosylation sequon Communications Biology. 4 :1,  941- DOI:10.1038/s42003-021-02473-8 PMID:34354228 
Seiya Oura, Taichi Noda, Naoko Morimura, Seiji Hitoshi, Hiroshi Nishimasu, Yoshitaka Nagai, Osamu Nureki, Masahito Ikawa (2021)  Precise CAG repeat contraction in a Huntington's Disease mouse model is enabled by gene editing with SpCas9-NG Communication Biology. 4 :1,  771- DOI:10.1038/s42003-021-02304-w PMID:34163001 
Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W. Moore, Tsunehiro Mizushima, Albena T. Dinkova-Kostova, Takuma Kasai, Takashi Kamei, Seizo Koshiba, Masayuki Yamamoto (2021)  Molecular basis for the disruption of Keap1-Nrf2 interaction via Hinge & Latch mechanism Communication Biology. 4 :1,  576- DOI:10.1038/s42003-021-02100-6 PMID:33990683 
Miho Watanabe-Takahashi, Masakazu Tamada, Miki Senda, Masahiro Hibino, Eiko Shimizu, Akiko Okuta, Atsuo Miyazawa, Toshiya Senda, Kiyotaka Nishikawa (2021)  Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin Comminications biology. 4 :1,  538- DOI:10.1038/s42003-021-02068-3 PMID:33972673 
Megumi Nishinaga, Hiroshi Sugimoto, Yudai Nishitani, Seina Nagai, Satoru Nagatoishi, Norifumi Muraki, Takehiko Tosha, Kouhei Tsumoto, Shigetoshi Aono, Yoshitsugu Shiro, Hitomi Sawai (2021)  Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival Communications Biology. 4 :1,  467- DOI:10.1038/s42003-021-01987-5 PMID:33850260 
Naoya Maekawa, Satoru Konnai, Maki Nishimura, Yumiko Kagawa, Satoshi Takagi, Kenji Hosoya, Hiroshi Ohta, Sangho Kim, Tomohiro Okagawa, Yusuke Izumi, Tatsuya Deguchi, Yukinari Kato, Satoshi Yamamoto, Keiichi Yamamoto, Mikihiro Toda, Chie Nakajima, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi (2021)  PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma. npj Precision Oncology - Nature. 5 :1,  10- DOI:10.1038/s41698-021-00147-6 PMID:33580183 
Jaeeun Lim , Eiko Sakai , Fuminori Sakurai & Hiroyuki Mizuguchi (2021)  miR-27b antagonizes BMP signaling in early differentiation of human induced pluripotent stem cells Scientifc Reports. 11 :1,  19820- DOI:10.1038/s41598-021-99403-9 PMID:34615950 
Takeshi Yamamotoya, Yusuke Nakatsu, Machi Kanna, Shun Hasei, Yukino Ohata, Jeffrey Encinas, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Takemasa Sakaguchi (2021)  Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target. Scientific Reports. 11 :1,  18581- DOI:10.1038/s41598-021-97972-3 PMID:34535740 
Halilibrahim Ciftci, Hiroshi Tateishi, Kotaro Koiwai, Ryoko Koga, Kensaku Anraku, Kazuaki Monde, Cagdas Dag, Ebru Destan, Busra Yuksel, Esra Ayan, Gunseli Yildirim, Merve Yigin, F Betul Ertem, Alaleh Shafiei, Omur Guven, Sabri O Besler, Raymond G Sierra, Chun Hong Yoon, Zhen Su, Mengling Liang, Burcin Acar, Turkan Haliloglu, Masami Otsuka, Fumiaki Yumoto, Mikako Fujita, Toshiya Senda, Hasan DeMirci (2021)  Structural insight into host plasma membrane association and assembly of HIV-1 matrix protein Scientific Reports. 11 :1,  15819- DOI:10.1038/s41598-021-95236-8 PMID:34349176 
Md.Altaf-Ul Amin, Kazuhisa Hirose, Joao V. Nani, Lucas C. Porta, Ljubica Tasic, Shaikh Farhad Hossain, Ming Huang, Naoaki Ono, MirianA. F. Hayashi, Shigehiko Kanaya (2021)  A system biology approach based on metabolic biomarkers and protein-protein interactions for identifying athways underlying schizophrenia and bipolar disorder Scientific Reports. 11 :1,  14450- DOI:10.1038/s41598-021-93653-3 PMID:34262063 
Yuta Yamamura, Kengo Furuichi, Yasuhiro Murakawa, Shigeki Hirabayashi, Masahito Yoshihara, Keisuke Sako, Shinji Kitajima, Tadashi Toyama, Yasunori Iwata, Norihiko Sakai, Kazuyoshi Hosomichi, Philip M Murphy, Atsushi Tajima, Keisuke Okita, Kenji Osafune, Shuichi Kaneko, Takashi Wada (2021)  Identification of candidate PAX2-regulated genes implicated in human kidney development Scientific Reports. 11 :1,  9123- DOI:10.1038/s41598-021-88743-1 PMID:33907292 
Yosuke Ito, Yasuhisa Terao, Shohei Noma, Michihira Tagami, Emiko Yoshida, Yoshihide Hayashizaki, Masayoshi Itoh, Hideya Kawaji (2021)  Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter Scientific Reports. 11 :1,  9355- DOI:10.1038/s41598-021-88018-9 PMID:33931666 
Kentaro Jingushi, Masaya Aoki, Kazuhiro Ueda, Takahiro Kogaki, Masaya Tanimoto, Yuya Monoe, Masayuki Ando, Takuya Matsumoto, Kentaro Minami, Yuko Ueda, Kaori Kitae, Hiroaki Hase, Toshiyuki Nagata, Aya Harada-Takeda, Masatatsu Yamamoto, Kohichi Kawahara, Kazuhiro Tabata, Tatsuhiko Furukawa, Masami Sato, Kazutake Tsujikawa (2021)  ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer scientific Reports. 11 :1,  8677- DOI:10.1038/s41598-021-87763-1 PMID:33883577 
Takaharu Sakuragi, Ryuta Kanai, Akihisa Tsutsumi, Hirotaka Narita, Eriko Onishi, Kohei Nishino, Takuya Miyazaki, Takeshi Baba, Hidetaka Kosako, Atsushi Nakagawa, Masahide Kikkawa, Chikashi Toyoshima, Shigekazu Nagata (2021)  The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes Nature Structural & Molecular Biology. 28 :10,  825-834 DOI:10.1038/s41594-021-00665-8 PMID:34625749 
Hiroyuki H Okamoto, Hirotake Miyauchi, Asuka Inoue, Francesco Raimondi, Hirokazu Tsujimoto, Tsukasa Kusakizako, Wataru Shihoya, Keitaro Yamashita, Ryoji Suno, Norimichi Nomura, Takuya Kobayashi, So Iwata, Tomohiro Nishizawa, Osamu Nureki (2021)  Cryo-EM structure of the human MT1-Gi signaling complex nature structural & molecular biology. 28 :8,  694-701 DOI:10.1038/s41594-021-00634-1 PMID:34354246 
Nathan Singh, Noelle V Frey, Boris Engels, David M Barrett, Olga Shestova, Pranali Ravikumar, Katherine D Cummins, Yong Gu Lee, Raymone Pajarillo, Inkook Chun, Amy Shyu, Steven L Highfill, Andrew Price, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xueqing Maggie Lu, David A Christian, Jessica Perazzelli, Simon F Lacey, Nathan H Roy, Janis K Burkhardt, Florent Colomb, Mohammad Damra, Mohamed Abdel-Mohsen, Ting Liu, Dongfang Liu, Daron M Standley, Regina M Young, Jennifer L Brogdon, Stephan A Grupp, Carl H June, Shannon L Maude, Saar Gill, Marco Ruella (2021)  Antigen-independent activation enhances the efficacy of 41BB co-stimulated CD22 CAR T cells. Nature Medicine. 27 :5,  842-850 DOI:10.1038/s41591-021-01326-5 PMID:33888899 
Yoshiaki Kise, Go Kasuya, Hiroyuki H. Okamoto , Daichi Yamanouchi , Kan Kobayashi, Tsukasa Kusakizako , Tomohiro Nishizawa, Koichi Nakajo & Osamu Nureki (2021)  Structural basis of gating modulation of Kv4 channel complexes Nature. DOI:10.1038/s41586-021-03935-z PMID:34552243 
Nagakumar Bharatham, Purnendu Bhowmik, Maho Aoki, Ui Okada, Sreevalli Sharma, Eiki Yamashita, Anirudh P. Shanbhag, Sreenath Rajagopal, Teby Thomas , Maitrayee Sarma, Riya Narjari, Savitha Nagaraj, Vasanthi Ramachandran, Nainesh Katagihallimath, Santanu Datta, Satoshi Murakami (2021)  Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae Nature Communications. 12 :1,  5400- DOI:10.1038/s41467-021-25679-0 PMID:34518546 
Tomoko Yamaguchi, Fumiaki Makino, Tomoko Miyata, Tohru Minamino, Takayuki Kato, Keiichi Namba (2021)  Structure of the molecular bushing of the bacterial flagellar motor. Nature Communications. 12 :1,  4469- DOI:10.1038/s41467-021-24715-3 PMID:34294704 
Radostin Danev , Matthew Belousoff , Yi-Lynn Liang , Xin Zhang , Fabian Eisenstein , Denise Wootten , Patrick M Sexton  (2021)  Routine sub-2.5 A cryo-EM structure determination of GPCRs Nature Communications. 12 :1,  4333- DOI:10.1038/s41467-021-24650-3 PMID:34267200 
Toshiko Yamazawa , Takuya Kobayashi , Nagomi Kurebayashi , Masato Konishi , Satoru Noguchi , Takayoshi Inoue , Yukiko U Inoue , Ichizo Nishino , Shuichi Mori , Hiroto Iinuma , Noriaki Manaka , Hiroyuki Kagechika, Arkady Uryash , Jose Adams , Jose R Lopez , Xiaochen Liu , Christine Diggle , Paul D Allen , Sho Kakizawa , Keigo Ikeda , Bangzhong Lin , Yui Ikemi , Kazuto Nunomura , Shinsaku Nakagawa , Takashi Sakurai , Takashi Murayama  (2021)  A novel RyR4-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke Nature Communications. 12 :1,  DOI:10.1038/s41467-021-24644-4 PMID:34257294 
Toshiko Yamazawa , Takuya Kobayashi , Nagomi Kurebayashi , Masato Konishi , Satoru Noguchi , Takayoshi Inoue , Yukiko U Inoue , Ichizo Nishino , Shuichi Mori , Hiroto Iinuma , Noriaki Manaka , Hiroyuki Kagechika, Arkady Uryash , Jose Adams , Jose R Lopez , Xiaochen Liu , Christine Diggle , Paul D Allen , Sho Kakizawa , Keigo Ikeda , Bangzhong Lin , Yui Ikemi , Kazuto Nunomura , Shinsaku Nakagawa , Takashi Sakurai , Takashi Murayama  (2021)  A novel RyR3-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke Nature Communications. 12 :1,  DOI:10.1038/s41467-021-24644-3 PMID:34257294 
Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R Lopez, Xiaochen Liu, Christine Diggle, Paul D Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama (2021)  A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke Nature Communications. 12 :1,  4293- DOI:10.1038/s41467-021-24644-1 PMID:34257294 
Yuya Yoshida , Naoya Matsunaga , Takaharu Nakao, Kengo Hamamura , Hideaki Kondo, Tomomi Ide, Hiroyuki Tsutsui, Akito Tsuruta, Masayuki Kurogi, Michio Nakaya, Hitoshi Kurose, Satoru Koyanagi & Shigehiro Ohdo  (2021)  Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis Nature communications. 12 :1,  2783- DOI:10.1038/s41467-021-23050-x PMID:33986294 
Makoto Saito, Yasushi Itoh, Fumihiko Yasui, Tsubasa Munakata, Daisuke Yamane, Makoto Ozawa, Risa Ito, Takayuki Katoh, Hirohito Ishigaki, Misako Nakayama, Shintaro Shichinohe, Kenzaburo Yamaji, Naoki Yamamoto, Ai Ikejiri, Tomoko Honda, Takahiro Sanada, Yoshihiro Sakoda, Hiroshi Kida, Thi Quynh Mai Le, Yoshihiro Kawaoka, Kazumasa Ogasawara, Kyoko Tsukiyama-Kohara, Hiroaki Suga, Michinori Kohara  (2021)  Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models nature communications. 12 :1,  2654- DOI:10.1038/s41467-021-22964-w PMID:33976181 
Aki Ishiyama, Rei Hokari, Kenichi Nonaka, Takuya Chiba, Hiromi Miura, Kazuhiko Otoguro, Masato Iwatsuki (2021)  Diatretol, an α, α'-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial The journal of antibiotics. 74 :4,  266-268 DOI:10.1038/s41429-020-00390-2 PMID:33446930 
Wei Zhou ,Naoe Kaneko,Tomoya Nakagita,Hiroyuki Takeda, Junya Masumoto (2021)  A comprehensive interaction study provides a potential domain interaction network of human death domain superfamily proteins Cell Death & Differentiation. DOI:10.1038/s41418-021-00796-x PMID:33993194 
Tomoki Niwa, Kousuke Nishibashi, Hitomi Sato, Kiyoshi Ujiie, Kenji Yamashita, Hiromichi Egami, Yoshitaka Hamashima (2021)  Structure Dependence in Asymmetric Deprotonative Fluorination and Fluorocyclization Reactions of Allylamine Derivatives with Linked Binaphthyl Dicarboxylate Phase-Transfer Catalyst Journal of the American Chemical Society. DOI:10.1021/jacs.1c06783 PMID:34590843 
Takashi Ikawa , Yuta Yamamoto , Akito Heguri , Yutaka Fukumoto , Tomonari Murakami , Akira Takagi , Yuto Masuda , Kenzo Yahata , Hiroshi Aoyama , Yasuteru Shigeta , Hiroaki Tokiwa , Shuji Akai  (2021)  Could London Dispersion Force Control Regioselective (2 + 2) Cyclodimerizations of Benzynes? YES: Application to the Synthesis of Helical Biphenylenes Journal of the American Chemical Society. 143 :29,  10853-10859 DOI:10.1021/jacs.1c05434 PMID:34197100 
Masanori Shigeno, Masaya Imamatsu, Yusuke Kai, Moe Kiriyama, Shintaro Ishida, Kanako Nozawa-Kumada, Yoshinori Kondo? (2021)  Construction of 1,2,3-Benzodiazaborole by Electrophilic Borylation of Azobenzene and Nucleophilic Dialkylative Cyclization Organic Letters. DOI:10.1021/acs.orglett.1c03033 PMID:34613748 
Kei Moritsugu, Norifumi Yamamoto, Yasushige Yonezawa, Shin-ichi Tate, and Hiroshi Fujisaki (2021)  Path ensembles for Pin1-catalyzed cis-trans isomerization of a substrate calculated by weighted ensemble simulations Journal of Chemical Theory and Computation. 17 :4,  2522-2529 DOI:10.1021/acs.jctc.0c01280 PMID:33769826 
Masatake Sugita , Satoshi Sugiyama , Takuya Fujie , Yasushi Yoshikawa , Keisuke Yanagisawa , Masahito Ohue , Yutaka Akiyama  (2021)  Large-Scale Membrane Permeability Prediction of Cyclic Peptides Crossing a Lipid Bilayer Based on Enhanced Sampling Molecular Dynamics Simulations Journal of Chemical Information and Modeling. 61 :7,  3681-3695 DOI:10.1021/acs.jcim.1c00380 PMID:34236179 
Keisuke Yanagisawa, Yoshitaka Moriwaki, Tohru Terada, Kentaro Shimizu (2021)  EXPRORER: Rational Cosolvent Set Construction Method for Cosolvent Molecular Dynamics Using Large-Scale Computation Journal of chemical information and modeling. 61 :6,  2744-2753 DOI:10.1021/acs.jcim.1c00134 PMID:34061535 
David Drew, Rachel A North, Kumar Nagarathinam, Mikio Tanabe (2021)  Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS) Chemical reviews. 121 :9,  5289-5335 DOI:10.1021/acs.chemrev.0c00983 PMID:33886296 
Takuya Hidaka, Wen Ann Wee, Ji Hye Yum, Hiroshi Sugiyama, Soyoung Park (2021)  Photo-Controllable Phase Transition of Arylazopyrazole-Conjugated Oligonucleotides Bioconjugate chemistry. DOI:10.1021/acs.bioconjchem.1c00302 PMID:34498851 
Waka Sakamoto, Nanako Azegami, Tsuyoshi Konuma, Satoko Akashi (2021)  Single-Cell Native Mass Spectrometry of Human Erythrocytes Analytical Chemistry. 93 :17,  6583-6588 DOI:10.1021/acs.analchem.1c00588 PMID:33871982 
Yohei Kawai, Ai Kawana-Tachikawa, Shuichi Kitayama, Tatsuki Ueda, Shoji Miki, Akira Watanabe, Shin Kaneko (2021)  Generation of highly proliferative rejuvenated cytotoxic T cell clones through pluripotency reprogramming for adoptive immunotherapy Molcular therapy. 29 :10,  3027-3041 DOI:10.1016/j.ymthe.2021.05.016 PMID:34023508 
Zhang Chun-ming, Imoto Yoshihiro, Hikima Takaaki, Inoue Tsuyoshi (2021)  Structural flexibility of the tetanus neurotoxin revealed by crystallographic and solution scattering analyses Journal of Structural Biology. X5 100045-105 DOI:10.1016/j.yjsbx.2021.100045 PMID:33598655 
Takahiro Noro, Juri Sakata, and Hidetoshi Tokuyama (2021)  Synthetic Studies on Discorhabdin V: Construction of the A-F Hexacyclic Framework Tetrahedron Letter. 81 153333-153336 DOI:10.1016/j.tetlet.2021.153333
Zhikuan Zhang, Hideki Shigematsu, Toshiyuki Shimizu, Umeharu Ohto (2021)  Improving particle quality in cryo-EM analysis using a PEGylation method. Structure. 29 :10,  1192-1199 DOI:10.1016/j.str.2021.05.004 PMID:34048698 
Zukang Feng, John D. Westbrook, Raul Sala, Oliver S. Samart, Gerald Bricogne, Masaak Matsubara, Issaku Yamada, Shinichiro Tsuchiya, Kiyoko F. Aoki-Kinoshita, Jefferey C. Hoch, Genji Kurisu, Sameer Velankar, Stephen K. Burley, Jasmine Y. Young (2021)  Enhanced validation of small-molecule ligands and carbohydrates in the Protein Data Bank Structure. 29 :4,  393-400 DOI:10.1016/j.str.2021.02.004 PMID:33657417 
Wataru Kagawa and Hitoshi Kurumizaka (2021)  Structural basis for DNA sequence recognition by pioneer factors in nucleosomes Structural Biology. 71 59-64 DOI:10.1016/j.sbi.2021.05.011 PMID:34218163 
Akiko Sagara, Kohei Nakata, Tomohiro Yamashita, Weiyu Guan, Pingshan Zhong, Sokichi Matsumoto, Sho Endo, Chika Iwamoto, Koji Shindo, Naoki Ikenaga, Taiki Moriyama, Kenoki Ohuchida, Kazuhiro Mizumoto, Masafumi Nakamura (2021)  New high-throughput screening detects compounds that suppress pancreatic stellate cell activation and attenuate pancreatic cancer growth Pancreatology. 21 1071-1080 DOI:10.1016/j.pan.2021.04.002 PMID:33965328 
Emma Rose McGlone, Yusman Manchanda, Ben Jones, Phil Pickford, Asuka Inoue, David Carling, Stephen R Bloom, Tricia Tan, Alejandra Tomas (2021)  Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling. Molecular Metabolism. 53 :101296,  DOI:10.1016/j.molmet.2021.101296 PMID:34271220 
Chisae Nagiri , Kazuhiro Kobayashi , Atsuhiro Tomita , Masahiko Kato , Kan Kobayashi , Keitaro Yamashita , Tomohiro Nishizawa , Asuka Inoue , Wataru Shihoya , Osamu Nureki  (2021)  Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity Molecular Cell. 81 :15,  3205-3215 DOI:10.1016/j.molcel.2021.06.024 PMID:34314699 
Takahiro Kogaki, Ikumi Ohshio, Hasumi Ura, Souta Iyama, Kaori Kitae, Toshiya Morie, Shintarou Fujii, Shohei Sato, Toshiyuki Nagata, Aya Harada Takeda, Masaya Aoki, Kazuhiro Ueda, Kentaro Minami, Masatatsu Yamamoto, Kohichi Kawahara, Tatsuhiko Furukawa, Masami Sato, Yuko Ueda, Kentaro Jingushi, Zenzaburo Tozuka, Daisuke Saigusa,Hiroaki Hase,?Kazutake Tsujikawa (2021)  Development of a highly sensitive method for the quantitative analysis of modified nucleosides using UHPLC-UniSpray-MS/MS Journal of Pharmaceutical and Biomedical Analysis. 197 113943- DOI:10.1016/j.jpba.2021.113943 PMID:33601155 
Takayuki Kimura, Nobuaki Yasuo, Masakazu Sekijima, Brooke Lustig (2021)  Statistical potentials for RNA-protein interactions optimized by CMA-ES Journal of Molecular Graphics and Modelling. 110 108044- DOI:10.1016/j.jmgm.2021.108044 PMID:34736056 
Kensuke Misawa, Yoshiya Sugai, Taketoshi Fujimori, Takatsugu Hirokawa (2021)  Structural insights from an in silico molecular docking simulation of complement component 3a receptor 1 with an antagonist J Mol Graph Model. 106 107914- DOI:10.1016/j.jmgm.2021.107914 PMID:33932736 
Hideaki Ohtomo, Jun-ichi Kurita, Shun Sakuraba, Zhenhai Li, Yasuhiro Arimura, Masatoshi Wakamori, Yasuo Tsunaka, Takashi Umehara, Hitoshi Kurumizaka, Hidetoshi Kono, Yoshifumi Nishimura (2021)  The N-terminal tails of histones H2A and H2B adopt two distinct conformations in the nucleosome with contact and reduced contact to DNA Journal of Molecular Biology. 433 :15,  167110- DOI:10.1016/j.jmb.2021.167110 PMID:34153285 
Hideki Itoh, Takashi Murayama, Nagomi Kurebayashi, SeikoOhno, Takuya Kobayashi, Yusuke Fujii, MasayaWatanabe, HaruoOgawa, Toshihisa Anzai, Minoru Horie (2021)  Sudden death after inappropriate shocks of implantablecardioverter defibrillator in a catecholaminergic polymorphicventricular tachycardia case with a novel RyR2 mutation Journal of Electrocardiology. 69 111-118 DOI:10.1016/j.jelectrocard.2021.09.015 PMID:34656916  
Keisuke Tachibana, Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Ryuichi Hirayama, Yumi Iwashita, Itsuki Nishino, Yukio Ago, Hiroyuki Takeda, Hiroki Kuniyasu, Masuo Kondoh (2021)  Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate Journal of Controlled Release. 336 105-111 DOI:10.1016/j.jconrel.2021.06.009 PMID:34118338 
Tensho Ten, Satoru Nagatoishi, Ryo Maeda, Masaru Hoshino, Yoshiaki Nakayama, Motoharu Seiki, Takeharu Sakamoto, Kouhei Tsumoto (2021)  Structural and thermodynamical insights into the binding and inhibition of FIH-1 by the N-terminal disordered region of Mint3 Journal of Biological Chemistry. DOI:10.1016/j.jbc.2021.101304 PMID:34655613 
Rie Uesugi, Shunsuke Ishii, Akira Matsuura, Eisuke Itakura (2021)  Labeling and Measuring Stressed Mitochondria Using a PINK1-Based Ratiometric Fluorescent Sensor Journal of Biological Chemistry. DOI:10.1016/j.jbc.2021.101279 PMID:34624312 
Takamasa Teramoto , Takeshi Koyasu , Naruhiko Adachi , Masato Kawasaki , Toshio Moriya , Tomoyuki Numata , Toshiya Senda , Yoshimitsu Kakuta (2021)  Minimal protein-only RNase P structure reveals insights into tRNA precursor recognition and catalysis Journal of Biological Chemistry. 297 :3,  101028- DOI:10.1016/j.jbc.2021.101028 PMID:34339732 
Hirofumi Ohashi, Koichi Watashi, Wakana Saso, Kaho Shionoya, Shoya Iwanami, Takatsugu Hirokawa, Tsuyoshi Shirai, Shigehiko Kanaya, Yusuke Ito , Kwang Su Kim, Takao Nomura, Tateki Suzuki, Kazane Nishioka, Shuji Ando, Keisuke Ejima, Yoshiki Koizumi, Tomohiro Tanaka, Shin Aoki, Kouji Kuramochi, Tadaki Suzuki, Takao Hashiguchi, Katsumi Maenaka, Tetsuro Matano, Masamichi Muramatsu, Masayuki Saijo, Kazuyuki Aihara, Shingo Iwami, Makoto Takeda, Jane A McKeating, Takaji Wakita (2021)  Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment iScience. 24 :4,  102367- DOI:10.1016/j.isci.2021.102367 PMID:33817567 
Takafumi Nakae, Masanori Obana, Takahiro Maeda, Akari Ikeda, Hiroshi Miyazaki, Shota Tanaka, Makiko Maeda, Kunihiko Yamashita, Kazuhiro Terai, Satoshi Obika, Yasushi Fujio (2021)  Gene Transfer by Pyro-Drive Jet Injector is a Novel Therapeutic Approach for Muscle Diseases Gene. 788 145664- DOI:10.1016/j.gene.2021.145664 PMID:33887371 
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Kenji Kawai, Masafumi Yamamoto,Hidetaka Kamimura, Yuichi Iida, Mitsuo Oshimura, Yasuhiro Kazuki, HiroshiYamazaki, Hayato Hikita, Tetsuo Takehara, Hiroshi Suemizu (2021)  An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals Drug Metabolism and Pharmacokinetics. DOI:10.1016/j.dmpk.2021.100410 PMID:34839181  
Takuya Hidaka, Kaori Hashiya, Toshikazu Bando, Ganesh N Pandian, Hiroshi Sugiyama (2021)  Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation Cell Chemical Biology. S2451-9456 :21,  00365-2- DOI:10.1016/j.chembiol.2021.08.003 PMID:34450110 
Masayasu Toyomoto, Asuka Inoue, Kei Iida, Masatsugu Denawa, Isao Kii, Francois Marie Ngako Kadji, Takayuki Kishi, Dohyun Im, Tatsuro Shimamura, Hiroshi Onogi, Suguru Yoshida, So Iwata, Junken Aoki, Takamitsu Hosoya, Masatoshi Hagiwara (2021)  S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation Cell Chemical Biology. 28 :8,  1132-1144 DOI:10.1016/j.chembiol.2021.01.004 PMID:33561428 
Mingming Chen, Miwako Asanuma, Mari Takahashi, Yuichi Shichino, Mari Mito, Koichi Fujiwara, Hironori Saito, Stephen N Floor, Nicholas T Ingolia, Mikiko Sodeoka, Kosuke Dodo, Takuhiro Ito, Shintaro Iwasaki (2021)  Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A Cell Chemical Biology. 28 :4,  475- DOI:10.1016/j.chembiol.2020.11.008 PMID:33296667 
Toshihiro Kobayashi, Aracely Castillo-Venzor, Chris A Penfold, Michael Morgan, Naoaki Mizuno, Walfred W C Tang, Yasuyuki Osada, Masao Hirao, Fumika Yoshida, Hideyuki Sato, Hiromitsu Nakauchi, Masumi Hirabayashi, M Azim Surani (2021)  Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cell Cell Reports. 37 :2,  109812- DOI:10.1016/j.celrep.2021.109812 PMID:34644585 
Xin Zhang , Matthew J Belousoff , Yi-Lynn Liang , Radostin Danev , Patrick M Sexton , Denise Wootten  (2021)  Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes Cell Reports. 36 :2,  109374- DOI:10.1016/j.celrep.2021.109374 PMID:34260945 
Kouichi Yanagi , Toru Komatsu, Shusuke Ogihara , Takayoshi Okabe , Hirotatsu Kojima , Tetsuo Nagano , Tasuku Ueno , Kenjiro Hanaoka , Yasuteru Urano  (2021)  Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells Cell Reports. 36 :1,  109311- DOI:10.1016/j.celrep.2021.109311 PMID:34233188 
Toi Kobayashi, Takumi Yasuno, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino, Tomoyuki Ohe (2021)  Novel pyridinium-type fullerene derivatives as multitargeting inhibitors of HIV-1 reverse transcriptase, HIV-1 protease, and HCV NS5B polymerase Bioorganic & Medicinal Chemistry Letters. 49 128267- DOI:10.1016/j.bmcl.2021.128267 PMID:34271071 
Yoshiaki Miyake, Masanori Obana, Takafumi Nakae, Ayaha Yamamoto, Shota Tanaka, Makiko Maeda, Yoshiaki Okada, Yasushi Fujio (2021)  PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis Biochemical and Biophysical Research Communications. 571 88-95 DOI:10.1016/j.bbrc.2021.07.067 PMID:34311199 
Jumpei Yokota , Tomoki Yamashita , Tatsuya Inui , Ryuga Nomoto , Wataru Kishimoto , Hiroshi Nakase , Hiroyuki Mizuguchi (2021)  Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studies Biochemical and Biophysical Research Communications. 566 115-122 DOI:10.1016/j.bbrc.2021.06.007 PMID:34119823 
Annika Bartsch, Callum M Ives, Christof Kattner, Florian Pein, Manuel Diehn, Mikio Tanabe, Axel Munk, Ulrich Zachariae, Claudia Steinem, Salome Llabres (2021)  An antibiotic-resistance conferring mutation in a neisserial porin: Structure, ion flux, and ampicillin binding. Biochimica Biophysica Acta - Biomembrane. 1863 :6,  183601- DOI:10.1016/j.bbamem.2021.183601 PMID:33675718 
Takeru Ebihara, Akitsu Masuda, Daisuke Takahashi, Masato Hino, Hiroaki Mon, Kohei Kakino, Tsuguru Fujii, Ryosuke Fujita, Tadashi Ueda, Jae Man Lee, Takahiro Kusakabe (2021)  Production of scFv, Fab, and IgG of CR3022 Antibodies Against SARS-CoV-2 Using Silkworm-Baculovirus Expression System molecular biotechnology. 63 :12,  1223-1234 DOI:10.1007/s12033-021-00373-0 PMID:34304364 
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Martin C Frith, Satomi Mitsuhashi, Kazutaka Katoh (2021)  lamassemble: Multiple alignment and consensus sequence of long reads. Methods in Molecular Biology. 2231 135-145 DOI:10.1007/978-1-0716-1036-7_9 PMID:33289891 
John Rozewicki, Songling Li, Kazutaka Katoh, Daron M Standley (2021)  Analysis of Protein Intermolecular Interactions with MAFFT-DASH. Methods in Molecular Biology. 2231 163-177 DOI:10.1007/978-1-0716-1036-7_11 PMID:33289893 
Andriy Kryshtafovych, John Moult, Wendy M Billings, Dennis Della Corte, Krzysztof Fidelis, Sohee Kwon, Kliment Olechnovic, Chaok Seok, Ceslovas Venclovas, Jonghun Won (2021)  Modeling SARS-CoV2 proteins in the CASP-commons experiment Prinsote. DOI:10.1002/prot.26231 PMID:34462960 
Ryo Kawakami, Miki Matsui, Ayumu Konno, Ryosuke Kaneko, Shreya Shrestha, Suman Shrestha, Hiroaki Sunaga, Hirofumi Hanaoka, Sawako Goto, Michihiro Hosojima, Hideyuki Kabasawa, Masaru Obokata, Norimichi Koitabashi, Hiroki Matsui, Tsutomu Sasaki, Akihiko Saito, Motoko Yanagita, Hirokazu Hirai, Masahiko Kurabayashi, Tatsuya Iso (2021)  Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury The Journal of pathology. DOI:10.1002/path.5775 PMID:34370295 
Tatsuhiko Ozawa, Eiji Kobayashi, Hiroshi Hamana, Tomoko Nakamura, Fulian Lyu, Atsushi Hayashi, Atsushi Muraguchi, Hiroyuki Kishi (2021)  Rapid and efficient generation of T-cell receptor-like antibodies using chip-based single-cell analysis European Journal of Immunology. 51 :7,  1850-1853 DOI:10.1002/eji.202049083 PMID:33728647 
Xue-ni Hou, Naotaka Sekiyama, Yasuko Ohtani, Feng Yang, Yohei Miyanoiri, Kenn-ichi Akagi, Xun-Cheng Su, Hidehito Tochio (2021)  Conformational space sampled by domain reorientation of linear diubiquitin reflected in its binding mode for target proteins Chemphyschem. 22 :14,  1505-1517 DOI:10.1002/cphc.202100187 PMID:33928740 
Daisuke Fujiwara, Kousuke Mihara, Ryo Takayama, Yusuke Nakamura, Mitsuhiro Ueda, Takeshi Tsumuraya, Ikuo Fujii (2021)  Chemical Modification of Phage-Displayed Helix-Loop-Helix Peptides to Construct Kinase-Focused Libraries ChemBioChem. DOI:10.1002/cbic.202100450 PMID:34605137 
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Takuya Naito, Kentaro Jingushi, Koji Ueda, Kazutake Tsujikawa (2021)  Azurocidin is loaded into small extracellular vesicles via its N-linked glycosylation and promotes intravasation of renal cell carcinoma cells FEBS Letters. 595 :19,  2522-2532 DOI:10.1002/1873-3468.14183 PMID:34418081