成果

高度化技術の応用と実際に創薬等先端技術支援基盤プラットフォームの高度化技術を使用した研究成果を紹介しています。

支援技術に関する成果

準備中

BINDSの支援を受けた研究成果

Shunsuke Itai, Shinji Yamada, Mika K. Kaneko, Hiroyuki Harada, Yukinari Kato (2017) Immunohistochemical analysis using antipodocalyxin monoclonal antibody PcMab-47 demonstrates podocalyxin expression in oral squamous cell carcinomas. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36:5, 220-223 (PMID:28873000).
Tomoyo Mohri, Yusuke Ogura, Ryo Towada, Shigefumi Kuwahara (2017) Enantioselective total synthesis of sacrolide A. Tetrahedron Letters. 58:42, 4011-4013.
Shunsuke Itai, Mika K. Kaneko, Yuki Fujii, Shinji Yamada, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Saori Handa, Yao-Wen Chang, Hiroyoshi Suzuki, Hiroyuki Harada, Yukinari Kato (2017) Development of EMab-51, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody in flow cytometry, western blot, and immunohistochemistry. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 36:5, 214-219 (PMID:28891752).
Yuko Ehara, Osamu Yamamoto, Kenjiro Kosaki, Yuichi Yoshida (2017) Natural course and characteristics of cutaneous neurofibromas in neurofibromatosis 1. Journal of Dermstology. in press (PMID:28891076).
Masataka Enoki, Saki Shinto, Yuta Matsuoka, Ayasa Otsuka, Sachiko Kaidzu, Masaki Tanito, Takahiro Shibata, Koji Uchida, Akihiro Ohira, Mayumi Yamato, Ken-ichi Yamada (2017) Lipid radicals cause light-induced retinal degeneration . Chemical Communications. 53:79, 10922--10925 (PMID:28930310).
Yuka Kobayashi, Tomoshi Kameda, Masaru Hoshino, Nobutaka Fujii, Hiroaki Ohno, Shinya Oishi (2017) Fe(II)-complexation of tripodal hexapeptide ligands with three bidentate triazolylpyridines: induction of metal-centred chirality by peptide macrocyclization. Dalton Transactions. 46:40, 13673_13676 (PMID:28951936).
Takao Arimori, Yu Kitago, Masataka Umitsu, Yuki Fujii, Ryoko Asaki, Keiko Tamura-Kawakami, Junichi Takagi (2017) Fv-clasp: An artificially designed small antibody fragment with improved production compatibility, stability, and crystallizability. Structure. 25:10, 1611-1622 (PMID:28919443).
Koun Onodera, Shumpei Baba, Akira Murakami, Tadashi Uemura, Tadao Usui (2017) Small conductance Ca2+-activated K+ channels induce the firing pause periods during the activation of Drosophila nociceptive neurons. Elife. 6, e29754 (PMID:29035200).
Hiroshi Kaneko,Takehide Katoh, Ikuo Hirano, Atsushi Hasegawa, Tadayuki Tsujita, Masayuki Yamamoto, Ritsuko Shimizu (2017) Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings. Genes to Cell. 22:11, 939-952 (PMID:29044949).
Atsushi Furukawa, Kosuke Kakita, Tomoki Yamada, Mikihiro Ishizuka, Jiro Sakamoto, Nanao Hatori, Naoyoshi Maeda, Fumina Ohsaka, Takashi Saitoh Takao Nomura, Kimiko Kuroki, Hisanori Nambu, Hisashi Arase, Shigeki Matsunaga, Masahiro Anada, Toyoyuki Ose, Shunichi Hashimoto, Katsumi Maenaka (2017) Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILR-α immune cell receptor. Journal of Bological Chemistry. in press (PMID:29046357).
Mizuki Nakamura, Sayaka Shibata, Toshihide Yamasaki, Megumi Ueno, Ikuo Nakanishi, Ken-ichiro Matsumoto, Tadashi Kamada, Ken-ichi Yamada, Ichio Aoki (2017) Feasibility of magnetic resonance redox imaging at low magnetic field: comparision at 1T and 7T. Amerincan Journal of Translational Research. 9:10, 4481-4491 (PMID:29118910).
Yuma Ishida, Yuka Okamoto, Yuta Matsuoka, Arisa Tada, Jindaporn Janprasit, Mayumi Yamato, Noppawan Phumala Morales, Ken-Ichi Yamada (2017) Detection and inhibition of lipid-derived radicals in low-density lipoprotein. Free Radical Biology and Medicine. 113, 487-493 (PMID:29107744).
Katsunori Takahashi, Haruhisa Kikuchi, Van Hai Nguyen, Yoshiteru Oshima, Hirotaka Ishigaki, Junko Nakajima-Shimada, Yuzuru Kubohara (2017) Biological activities of novel derivatives of differentiation-inducing factor 3 from Dictyostelium discoideum. Biological and Pharmaceutical Bulletin. 40:11, 1941-1947 (PMID:29093342).
Shuichi Mori, Ryohei Takagaki, Shinya Fujii, Ko Urushibara, Aya Tanatani, Hiroyuki Kagechika (2017) Novel non-steroidal progesterone receptor ligands based on m-carborane containing a secondary alcohol: Effect of chirality on ligand activity. Chemical and Pharmaceutical Bulletin. 65:11, 1051-1057 (PMID:29093292).
Itai Shunsuke, Yamada Shinji, Kaneko Mika K., Harada Hiroyuki, Kagawa Yumiko, Konnai Satoru, Kato Yukinari (2017) Expression of cat podoplanin in feline squamous cell carcinomas. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. in press (PMID:29090969).
Itai Shunsuke, Yamada Shinji, Kaneko Mika K., Chang Yao-Wen, Harada Hiroyuki, Kato Yukinari (2017) Establishment of EMab-134, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody for detecting squamous cell carcinoma cells of the oral cavity. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. in press (PMID:29090976).
Masako Koyama, Hitoshi Kurumizaka (2017) Structural diversity of the nucleosome. Journal of Biochemistry. in press (PMID:29161414).
Zuben P. Brown, Takao Arimori, Kenji Iwasaki, Junichi Takagi (2017) Development of a new protein labeling system to map subunits and domains of macromolecular complexes for electron microscopy. Journal of Structural Biology. in press (PMID:29170031).
Gengo Kashiwazaki, Rina Maeda, Takashi Kawase, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2018) Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer. Bioorganic & Medicinal Chemistry. 26:1, 1-7 (PMID:29224995).
Yuri Sakai, Atsushi Kawaguchi, Kyosuke Nagata, Takatsugu Hirokawa (2017) Binding pathway analysis of influenza virus M2 channel blockers by metadynamics simulation. Microbiology and Immunology. in press (PMID:29210473).
Shohei Mori, Kunihiko Morihiro, Takumi Okuda, Yuuya Kasahara, Satoshi Obika (2017) Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides. Royal Society of Chemistry. in press.
Toshimune Nomura, Satoshi Yokoshima, Tohru Fukuyama (2017) Total synthesis of huperzine R. Organic letters. in press (PMID:29219324).
Fumihito_Miura, Takashi_Ito (2017) Post-bisulfite adaptor tagging for PCR-free whole-genome bisulfite sequencing. DNA Methylation Protocols. 1708, 123-136 (PMID:29224142).

出願特許一覧(公開可能なもののみ)

準備中

公開特許一覧表

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成立特許一覧表

準備中